EEG Source Extraction by Autoregressive Source Separation Reveals Abnormal Synchronization in Parkinson's Disease.

Recent research efforts in studying brain connectivity has provided new perspectives to understanding of neurophysiology of brain function. Connectivity measures are typically computed from electroencephalogram (EEG) signals, yet the presence of volume conduction makes interpretation of results difficult. One possible alternative is to model the connectivity in the source space. In this study, we proposed a novel source separation technique in which EEG signals are represented as a state-space framework. The framework jointly models the underlying brain sources and the connectivity between them in the form of a generalized autoregressive (AR) process. The proposed technique was applied to real EEG data collected from normal and Parkinson's patients during a motor task. The extracted sources revealed the abnormal beta activity in Parkinson's subjects and showed similar biological networks as previous studies.