The effect of bee bread (BB) on the biochemical parameters-body weights, calorie intake, Lee obesity indices, serum amylase, aspartate and alanine amino transferases, skeletal muscle activities of creatine kinase, superoxide dismutase, glutathione peroxidase, catalase, malondialdehyde, glutathione-S-transferase, total antioxidant activity, endogenous secretory receptor for advanced glycation end products (esRAGE), and muscle histology of high-fat diet (HFD) obese rats-was studied. Thirty-six male Sprague-Dawley rats were divided into six groups: Control: received rat feed and water (1 ml/kg); HFD: received HFD and water (1 ml/kg): BB or orlistat preventive: received HFD and BB (0.5 g/kg) or HFD and orlistat (10 mg/kg; weeks 1 to 12); BB or orlistat treated: received HFD and BB (0.5 g/kg) or HFD and orlistat (10 mg/kg; weeks 6 to 12), following obesity induction. At week 12, HFD group had altered (p < .05) levels of some biochemical parameters which were modulated by BB and corroborated by muscle histology. Practical applications Obesity is a global health problem, which prevalence has continued to be on the increase due to changes in lifestyle and dietary behavior. Additionally, the approaches that currently are being used for the treatment of this disease have not been able to successfully reverse obesity and its associated complications. The current study which showed that bee bread prevented or attenuated obesity-induced muscular pathology, places bee bread in the spotlight as a functional food that could be useful in preventing or mitigating obesity-induced muscular pathology.
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