Electrical and Calcium Signaling of Nerve and Muscle in Unicellular Choanoflagellates

J. David Spafford,Amrit Mehta, Shazah Waqar, Prashanth S. Velayudhan, Jonathan Fan, Tarun Sharma, Anitha Bhat, Zaid Alsamman, Curtis Jeffery,Veronika Magdanz, Afnan Alsakani

Biophysical Journal（2024）SCI 2区

Univ Waterloo

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摘要

Choanoflagellates are the only non-animals to contain key homologs of voltage-gated channels required for generating spontaneous action potentials. Action potentials activate high voltage-gated CaV channels which mediate neurotransmitter secretion at presynaptic nerve terminals (CaV2.1, CaV2.2), neuro-endocrine cells (CaV2.3) or sensory ribbon synapses associated with hearing (CaV1.3) and vision (CaV1.4). Cav1 channels in T-tubules align with ryanodine receptors of opposing sarcoplasmic reticulum (SR) membranes to mediate skeletal (CaV1.1) and cardiac (CaV1.2) muscle contractions.

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