Epigenetic Silencing and Pharmacological Inhibition of EIF5A2 Foster Venetoclax Sensitivity in Acute Myeloid Leukaemia

We show how the loss of activity of the translation initiation factor EIF5A2-either through gene hypermethylation or pharmacologic inhibition of its highly specific hypusine post-translational modification-induces venetoclax sensitivity in acute myeloid leukaemia (AML) cells.