In this paper 1 1 The work was done when the authors were with Futurewei Technologies, Bridgewater, NJ., we present a state-of-the-art method to estimate block error rate (BLER) for coded modulation with practical channel codes, e.g., turbo or low-density parity-check (LDPC) codes. The method is based on the theoretic breakthrough on the finite block coding and a novel rate combining model. With tuning on a very limited number of parameters, the estimates from the proposed method match very well with the simulation results. The proposed method can have wide ranges of applications for wireless communications.