Faculty Opinions Recommendation of How Can Hearing Loss Cause Dementia?

Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this relationship. These bases include a common pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished listening environment, and the occupation of cognitive resources when listening in difficult conditions. We also put forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition. In particular, we consider how aberrant activity in the service of auditory pattern analysis, working memory, and object processing may interact with dementia pathology in people with hearing loss. We highlight how the effect of hearing interventions on dementia depends on the specific mechanism and suggest avenues for work at the molecular, neuronal, and systems levels to pin this down.Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved. PMID: 32871106 Funding information This work was supported by: Medical Research Council, United Kingdom Grant ID: MR/T032553/1 Wellcome Trust, United Kingdom Grant ID: WT106964MA NIDCD NIH HHS, United States Grant ID: R01 DC004290 NIDCD NIH HHS, United States Grant ID: P50 DC000242 Wellcome Trust, United Kingdom Grant ID: 210567/Z/18/Z Wellcome Trust, United Kingdom More Less keyboard_arrow_down