Family Empowerment Education Module for Parents of Children with Thalassemia Major: a Randomized Controlled Study on Anxiety, Problem-Solving, and Psychological Resilience.

OBJECTIVE:This study determined the effect of the Family Empowerment in Pediatric Thalassemia Care (FE-PTC) Module on anxiety, problem-solving skills and psychological resilience in parents of children with thalassemia major. METHOD:In this randomized controlled study, 76 parents of children with thalassemia major followed in a thalassemia unit were randomly assigned to an intervention (n = 36) or control (n = 40) group between December 2025 and April 2026. The intervention group received the FE-PTC Module, structured on the Family-Centered Empowerment Model; the control group received routine care. Data were collected at pre-test and post-test using an Information Form, the Generalized Anxiety Disorder-7, the Problem-Solving Inventory and the Brief Resilience Scale, and analysed using mixed ANOVA and one-way ANCOVA adjusted for baseline scores. FINDINGS:The groups were comparable at baseline (p > 0.05). Relative to controls, the intervention group showed lower post-test anxiety (adjusted mean difference = -5.62; 95% CI: -7.78 to -3.46; p < 0.001; ηp2 = 0.190), lower, that is more favourable, problem-solving scores (-2.77; 95% CI: -4.52 to -1.02; p = 0.002; ηp2 = 0.130) and higher psychological resilience (+2.44; 95% CI: 1.08 to 3.80; p = 0.001; ηp2 = 0.150). CONCLUSION:FE-PTC is an effective, evidence-based and implementable nursing intervention for reducing anxiety and improving problem-solving skills and psychological resilience in parents of children with thalassemia. IMPLICATIONS FOR PRACTICE:FE-PTC gives pediatric nurses a structured, low-cost protocol deliverable within existing transfusion and outpatient visits, without additional staffing or technology. Routine psychosocial screening of parents early after diagnosis, with referral to structured empowerment programmes, is warranted in thalassemia units.