Metal rubber is a key damping material in aerospace and other fields, whose fatigue damage is closely related to the vibration isolation effectiveness and safety of the system. This study investigates the influence of relative density and wire diameter on the wear evolution and performance degradation of metal rubber vibration isolators through accelerated fatigue experiments, vibration characteristic tests, and microscopic morphology observation, along with a neural network-based prediction model. The results indicate that increasing the wire diameter not only delays stiffness attenuation but also enhances performance stability under random and impact loads. In contrast, a higher relative density improves initial stiffness but accelerates performance degradation due to aggravated wear.