The mutational spectrum of CH in 986 patients with multiple myeloma. A, The total number of patients harboring one or more mutations in each gene. B, Number of patients harboring mutations in one or two different genes. C, Commutation plot showing CH, tumor and germline mutations present in 129 patients: each column represents a single patient. The top row denotes the maximum VAF in each patient, with darker shades of red indicating higher VAF. The bar graph on the right designates the percentage of the different mutation subtypes for each gene out of all detected mutations.