Output of natural splines for most prevalent cancers. Figure shows the output of natural splines conducted on incidence by longitude and time zone for four of the most prevalent cancers, with 95% bootstrap confidence band. A, Liver and bile duct cancer (without MST, n = 1,063). B, Lung and bronchus cancer (n = 2,441). C, Colon and rectum cancer (n = 1,955). D, Pancreas cancer (n = 1,191).