Figure 3 from Modeled Benefit of Individual Cancer Signal Origin Prediction for Multi-Cancer Early Detection

Overall PPVs modeled for each CSO prediction by age. Cancer incidence increases with age, and in this model, FPs are constant across age groups, so the PPV increases with age. Importantly, despite minor changes in relative incidence of cancer types with age, the PPV still indicates a noticeable risk of cancer within each age range. The dashed line represents a threshold PPV of 7%, typically justifying workup.