Figure S13 from Application of Novel Breast Biospecimen Cell-Type Adjustment Identifies Shared DNA Methylation Alterations in Breast Tissue and Milk with Breast Cancer–Risk Factors

Epigenome-wide association analysis identifying CpG sites that are significantly differentially methylated in women with a family history of breast cancer relative to women without a family history of breast cancer in (A) solid breast tissue and (B) breast milk, adjusted for estimated proportions of epithelial cells, endothelial cells, fibroblasts, adipocytes, monocytes, and neutrophils. (C) Overlap of identified hypermethylated and hypomethylated loci (P < 0.01) in solid breast tissue and breast milk.