Front Cover: Cryo‐kinetics Reveal Dynamic Effects on the Chemistry of Human Dihydrofolate Reductase (chembiochem 14/2021)

Isotopologues, enzymes that differ only in their isotopic substitution, engage in a tug of war to determine the role of protein motions and electrostatics for catalysis. The features of the ribbon diagrams indicate that the enzymes are human dihydrofolate reductases. More information can be found in the Communication by R. K. Allemann et al.