Further Considerations on Adverse Childhood Experiences and Neurocognitive Development.

ImportanceEarly life adversity is associated with higher risk of many adult health problems, including mental illness, substance abuse, suicide attempt, and chronic diseases. Many previous studies investigated adversities one at a time or investigated the health toll associated with the cumulative number of adversities.ObjectiveTo examine the co-occurrence of adversities among children and how specific patterns of adversities are associated with neurocognitive development.Design, Setting, and ParticipantsThis cohort study used data from the Collaborative Perinatal Project (CPP), which enrolled a national sample of women during pregnancy and followed their offspring to ages 7 to 8 years, between 1959 and 1974. The CPP was a community-based study conducted in 12 US medical centers. The CPP sample was ascertained through prenatal clinics and is diverse with respect to race and socioeconomic status. Data analysis was performed from August 2023 to March 2024.ExposuresA latent class analysis was conducted of 12 adverse childhood experiences that occurred between birth and 7 years to identify common patterns of childhood adversities.Main Outcomes and MeasuresFive neurocognitive tests were used to measure children’s visual-motor, sensory-motor, auditory-vocal, intelligence quotient, and academic skills.ResultsThe analysis sample included 49 853 offspring (25 226 boys [50.6%]); 24 436 children (49.0%) had low probability of experiencing any adversity, whereas the remaining half were classified into 5 groups reflecting distinct patterns of childhood adversities: parental harshness and neglect, 1625 children (3.3%); parental separation and poverty, 8731 children (17.5%); family instability, 3655 children (7.3%); family loss, instability, and poverty, 1505 children (3.0%); and crowded housing and poverty, 9901 children (19.9%). Children in 4 of these groups had lower neurocognitive scores than children with a low probability of experiencing adversity, with standardized mean differences ranging from −0.07 (95% CI, −0.11 to −0.03) to −0.86 (95% CI, −1.06 to −0.65).Conclusions and RelevanceThese findings suggest that adverse childhood experiences are associated with deficits in children’s neurocognitive functions. It is important to understand the complexity in children’s exposure to adversity and the resulting developmental consequences, as well as the underlying mechanisms, to help support children exposed to adversity and foster healthier and resilient trajectories of development.