Abstract This chapter looks at both neurological and cognitive research to explore where gesture resides in the physical brain and how it contributes to the processes of the mind. In relation to neurological research, gesture is part of the sensorimotor system. Gesture is also closely linked with language in the brain, activating many of the same regions, including Broca’s and Wernicke’s areas. Gesture use varies with neurotype and is shown to suffer similar impairment to language for people with acquired brain injuries. Cognitive models allow us to consider the evidence from language and gesture production to build an understanding of the sequence of steps required to move from the abstract processes of thought to the concrete production of speech and gesture. This chapter summarizes key models of language and gesture production, models for understanding the relationship between gesture, movement, and thought, and models of gesture perception and processing.