Glutamate: A Neurotransmitter in Mammalian Brain

Journal of NeurochemistryVolume 42, Issue 1 p. 1-11 Free Access Glutamate: A Neurotransmitter in Mammalian Brain Frode Fonnum, Corresponding Author Frode Fonnum Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller, NorwayAddress correspondence and reprint requests to Frode Fonnum, Norwegian Defence Research Establishment, Division for Environmental Toxicology, N-2007 Kjeller, Norway.Search for more papers by this author Frode Fonnum, Corresponding Author Frode Fonnum Norwegian Defence Research Establishment, Division for Environmental Toxicology, Kjeller, NorwayAddress correspondence and reprint requests to Frode Fonnum, Norwegian Defence Research Establishment, Division for Environmental Toxicology, N-2007 Kjeller, Norway.Search for more papers by this author First published: January 1984 https://doi.org/10.1111/j.1471-4159.1984.tb09689.xCitations: 1,542AboutSectionsPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abbreviations used: GAB A δ-Aminobutyric acid HRP Horseradish peroxidase NMDA N-Methyl-D-aspartate REFERENCES Abdul-Ghani, A. S., Bradford, H. F., Cox, D. W. G., and Dodd, P. R. (1979) Peripheral sensory stimulation and the release of transmitter amino acids in vivo from specific regions of cerebral cortex. Brain Res. 171, 55– 56. CrossrefCASPubMedWeb of Science®Google Scholar Altschuler, F. R., Neises, G. R., Harmison, G. C., Wenthold, R. J., and Fex, J. (1981) Immunocytochemical localization of as-partate aminotransferase immunoreactivity in cochlear nucleus of the guinea pig. Proc. Natl. Acad. Sci. USA 78, 6553– 6557. CrossrefCASPubMedWeb of Science®Google Scholar Altschuler, R. A., Mosinger, J. L., Harmison, G. G., Parakkal, M. H., and Wenthold, R. J. (1982) Aspartate aminotransferase-like immunoreactivity as a marker for aspartate/glutamate in guinea pig photoreceptors. Nature 298, 657– 659. CrossrefCASPubMedWeb of Science®Google Scholar Balazs, R., Machiyama, Y., Hammond, B. J., Julian, T., and Richter, D. (1970) The operation of the γ-aminobutyrate bypath of the tricarboxylic acid cycle in brain tissue in vitro. Biochem. J. 116, 445– 467. CrossrefCASPubMedWeb of Science®Google Scholar Balcar, V. J. and Johnston, G. A. R. (1972) The structural specificity of the high affinity uptake of L-glutamate and L-aspartate by rat brain slices. J. Neurochem. 19, 2657– 2666. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Balcar, V. J., and Johnston, G. A. R. (1973) High affinity uptake of transmitters: studies on the uptake of L-aspartate, GABA, L-glutamate and glycine in cat spinal cord. J. Neurochem. 20, 529– 539. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Balcar, V. J., Borg, J., and Mandel, P. (1977) High affinity uptake of L-glutamate and L-aspartate by glial cells. J. Neurochem. 28, 87– 93. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Baughman, R. W. and Gilbert, C. D. (1981) Aspartate and glutamate as possible neurotransmitters in the visual cortex. J. Neurosci. 1, 427– 439. CASPubMedWeb of Science®Google Scholar Baudry, M., Seman, R., Smith, E. W., and Lynch, G. (1983) Regulation by calcium ions of glutamate receptor binding in hip-pocampal slices. Eur. J. Pharmacol. 90, 161– 166. CrossrefCASPubMedWeb of Science®Google Scholar Berl, S. and Clarke, D. D. (1978) Metabolic compartmentation of the glutamate-glutamine system; glial contribution, in Amino Acids as Chemical Transmitters ( F. Fonnum, ed), pp. 691– 708. Plenum Press, New York . CrossrefWeb of Science®Google Scholar Bennet Logan, W. J., and Snyder, S. W. (1973) Amino acids as central nervous transmitters. The influence of ions, amino acid analogues and ontogeny on transport systems for L-glutamic and L-aspartic acids and glycine into central nervous synaptosomes of the rat. J. Neurochem. 21, 1533– 1550. Wiley Online LibraryPubMedGoogle Scholar Berl, S., Lajtha, A., and Waelsch, H. (1961) Amino acid and protein metabolism. VI. Cerebral compartments of glutamic acid metabolism. J. Neurochem. 7, 186– 197. Wiley Online LibraryCASWeb of Science®Google Scholar Berl, S., Takagaki, G., Clarke, D. D., and Waelsch, H. (1962) Metabolic compartments in vivo: ammonia and glutamic acid metabolism in brain and liver. J. Biol. Chem. 237, 2562– 2569. CASPubMedWeb of Science®Google Scholar Blaustein, M. P. (1975) Effects of potassium, veratridine and scorpion venom on calcium accumulation and transmitter release by nerve terminals in vivo. J. Physiol. (Lond.) 247, 617– 653. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Bowey, N. G., Brown, D. A., and Marsh, S. (1979) γ-Aminobutyric acid efflux from sympathetic glial cells: effect of depolarizing agents. J. Physiol. (Lond.), 293, 75– 90. Wiley Online LibraryPubMedWeb of Science®Google Scholar Bradford, H. F. and Ward, H. K. (1976) On glutaminase in mammalian synaptosomes. Brain. Res. 110, 115– 125. CrossrefCASPubMedWeb of Science®Google Scholar Bradford, H. R., Ward, H. K., and Tomas, A. J. (1978) Glutamine---a major substrate for nerve endings. J. Neurochem. 30, 1453– 1459. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Canzek, V. and Reubi, J. C. (1980) The effect of cochlear nerve lesion on the release of glutamate, aspartate and GABA from the cochlear nucleus in vitro. Exp. Brain Res. 38, 437– 441. CrossrefCASPubMedWeb of Science®Google Scholar Clark, R. M., and Collins, G. G. S. (1975) The spontaneous and potassium-evoked release of endogenous amino acids from the mammalian visual cortex. J. Physiol. (Lond.) 246, 16– 17. Google Scholar Clark, R. M. and Collins, G. G. S. (1976) The release of endogenous amino acids from the rat visual cortex. J. Physiol. (Lond.), 262, 383– 400. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Clarke, D. D., Ronan, E. J., Dicker, E., and Tirri, L. (1975) Ethanol and its relation to amino acid metabolism in brain, in Metabolic Compartmentation and Neurotransmission ( S. Berl, D. D. Clarke, and D. Schneider, eds), pp. 449– 460. Plenum Press, New York . CrossrefWeb of Science®Google Scholar Collins, G. G. S. (1980) Release of endogenous amino acid neurotransmitter candidates from rat olfactory cortex slices: possible regulatory mechanisms and the effects of pentobarbitone. Brain Res. 190, 517– 528. CrossrefCASPubMedWeb of Science®Google Scholar Collins, G. G. S. and Probett, G. A. (1981) Aspartate and not glutamate is the likely transmitter of the rat lateral olfactory tract fibres. Brain Res. 201, 231– 234. CrossrefWeb of Science®Google Scholar Cotman, C. W., Foster, A., and Lanthorn, T. (1981) An overview of glutamate as a neurotransmitter, in Glutamate as a Neu-rotransmitter ( G. DiChiara and G. L. Gessa, eds), pp. 1– 27. Raven Press, New York . Web of Science®Google Scholar Coyle, J. T. (1983) Neurotoxic action of kainic acid. J. Neurochem. 41, 1– 11. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Crawford, I. L. and Connor, J. D. (1973) Localization and release of glutamic acid in relation to the hippocampal mossy fibre pathway. Nature 244, 442– 443. CrossrefCASPubMedWeb of Science®Google Scholar Cremer, J. E., Heath, D. R., Patel, A. J., Balazs, R., and Cavanagh, J. B. (1975) An experimental model of CNS changes associated with chronic liver disease: portocaval anastomosis in the rat, in Metabolic Compartmentation and Neurotransmission ( S. Berl, D. D. Clarke, and D. Schneider, eds), pp. 461– 478. Plenum Press, New York . CrossrefGoogle Scholar Cuenod, M., Beaudet, A., Canzek, V., Streit, P., and Reubi, J. C. (1981) Glutamergic pathways in the pigeon and in the rat brain. Adv. Biochem. Psychopharmacol. 27, 57– 68. CASPubMedGoogle Scholar Curtis, D. R. and Johnston, G. A. R. (1974) Amino acid transmitters in the mammalian central nervous system. Ergebn. Physiol. 69, 94– 188. Google Scholar Curtis, D. R. and Watkins, J. C. (1961) The chemical excitation of spinal neurons by certain amino acids. J. Physiol. (Lond.) 166, 1– 14. Wiley Online LibraryPubMedWeb of Science®Google Scholar Davidoff, R. A., Graham, L. T., Shank, R. P., Werman, R., and Aprison, M. H. (1967) Changes in amino acid concentrations associated with loss of spinal interneurons. J. Neurochem. 14, 1025– 1031. Wiley Online LibraryCASPubMedGoogle Scholar Davies, L. P. and Johnston, G. A. R. (1976) Uptake and release of D-and L-aspartate by rat brain slices. J. Neurochem. 26, 1007– 1014. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar de Barry, J., Langley, O. K., Vincendon, G., and Gombos, G. (1982) L-glutamate and L-glutamine uptake in adult rat cerebellum: an autoradiographic study. Neuroscience 7, 1289– 1297. CrossrefPubMedWeb of Science®Google Scholar de Belleroche, J. S. and Bradford, H. F. (1972) Metabolism of beds of mammalian cortical synaptosomes: response to depolarizing influences. J. Neurochem. 19, 525– 602. Wiley Online LibraryPubMedWeb of Science®Google Scholar de Belleroche, J. S. and Bradford, H. F. (1973) Amino acids in synaptic vesicles from mammalian cerebral cortex: a reappraisal. J. Neurochem. 21, 441– 451. Wiley Online LibraryPubMedWeb of Science®Google Scholar DiChiara, G., and Gessa, G. L. (1981) Glutamate as a Neurotransmitter. Raven Press, New York . Google Scholar Dolly, J. O., Tse, C. K., Spokes, J. W., and Diniz, C. R. (1978) Effects of β-bungarotoxin and Tityus toxin on uptake and release of neurotransmitters. Biochem. Soc. Trans. 6, 652– 654. PubMedGoogle Scholar Duce, I. R. and Keen, P. (1983) Selective uptake of [3H]glutamine and [3H]glutahiate into neurons and satellite cells of dorsal root ganglia in vitro. Neuroscience 8, 861– 866. CrossrefCASPubMedWeb of Science®Google Scholar Ellory, J. C., Jones, S. E. M., and Young, J. D. (1981) Glycine transport in human erythrocytes. J. Physiol. (Lond.) 320, 403– 422. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Engelsen, B. and Fonnum, F. (1982) Effects of hypoglycemia on transmitter and non-transmitter glutamate. Acta Neurol. Scand. (Suppl. 90) 65, 63– 64. Google Scholar Fagg, G. E., Foster, A. C., Mena, E. E., and Cotman, C. W. (1982) Chloride and calcium ions reveal a pharmacological distinct population of L-glutamate binding sites in synaptic membranes: correspondence between biochemical and electrophysiological data. J. Neurosci. 2, 958– 965. CrossrefCASPubMedWeb of Science®Google Scholar Fonnum, F. (1968) The distribution of glutamate decarboxylase and aspartate transaminase in subcellular fractions of rat and guinea-pig brain. Biochem. J. 106, 401– 412. CrossrefCASPubMedWeb of Science®Google Scholar F. Fonnum, (Ed.) (1978) Amino Acids as Chemical Transmitters, NATO Advanced Study Institutes Series, Series A, Life Sciences; Vol. 16. Plenum Press, New York . Google Scholar Fonnum, F. (1981) The turnover of transmitter amino acids with special reference to GABA, in Central Neurotransmitter Turnover. ( C. J. Pycock and P. V. Taberner, eds), pp. 105– 124. University Park Press, Baltimore . CrossrefPubMedGoogle Scholar Fonnum, F. and Walaas, I. (1978) The effect of intrahippocampal kainic acid injections and surgical lesions on neurotransmitters in hippocampus and septum. J. Neurochem. 31, 1173– 1181. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Fonnum, F, and Walberg, F. (1973) An estimation of the concentration of γ-aminobutyric acid and glutamate decarboxylase in the inhibitory Purkinje axon terminals of the cat. Brain Res. 54, 115– 127. CrossrefCASPubMedWeb of Science®Google Scholar Fonnum, F., Lund-Karlsen, R., Malthe-Sørenssen, D., Skrede, K. K., and Walaas, I. (1979) Localization of neurotransmitters, particularly glutamate, in hippocampus, septum, nucleus accumbens and superior colliculus. Progr. Brain Res. 51, 167– 191. CrossrefCASPubMedGoogle Scholar Fonnum, F., Lund-Karlsen, R., Malthe-Sørenssen, D., Sterri, S., and Walaas, I. (1980) High affinity transport systems and their role in transmitter action, in The Cell Surface and Neuronal Function, ( C. W. Cotman, G. Poste, and G. L. Nicholson, eds), pp. 455– 504. Elsevier/North-Holland Biomedical Press, Amsterdam . PubMedWeb of Science®Google Scholar Fonnum, F., Storm-Mathisen, J., and Divac, I. (1981a) Biochemical evidence for glutamate as neurotransmitter in the cortico-striatal and cortico-thalamic fibres in rat brain. Neuroscience 6, 863– 875. CrossrefCASPubMedWeb of Science®Google Scholar Fonnum, F., Søreide, A., Kvale, I., Walker, J., and Walaas, I. (1981b) Glutamate in corticofugal fibres in glutamate as a neurotransmitter in Advances in Biochemical Psychopharmacology, Vol. 27 ( G. Chiara and G. L. Gessa, eds), pp. 29– 41. Raven Press, New York . Google Scholar Godukhin, O. V., Zharikova, A. D., and Novoselov, V. I. (1980) The release of labeled L-glutamic acid from rat neostriatum in vivo following stimulation of frontal cortex. Neuroscience 5, 2151– 2154. CrossrefCASPubMedWeb of Science®Google Scholar Graham Aprison, M. H. (1969) Distribution of some enzymes associated with the metabolism of aspartate, glutamate, γ-aminobutyrate and glutamine in cat spinal cord. J. Neurochem. 16, 559– 566. Wiley Online LibraryPubMedWeb of Science®Google Scholar Haldeman, S. and Mc Lennan, H. (1972) The antagonistic action of glutamic acid diethylester towards amino acid-induced and synaptic excitation of central neurones. Brain Res. 45, 393– 400. CrossrefCASPubMedWeb of Science®Google Scholar Haldeman, S. and Mc Lennan, H. (1973) The action of two inhibitors of glutamic acid uptake upon amino acid-induced and synaptic excitations of thalamic neurones. Brain Res. 63, 123– 129. CrossrefCASPubMedWeb of Science®Google Scholar Hamberger, A., Chiang, G. H., Nylén, E. S., Scheff, S. W., and Cotman, C. W. (1979a) Glutamate as a CNS transmitter. I. Evaluation of glucose and glutamine as precursors for the synthesis of preferentially released glutamate. Brain Res. 168, 513– 530. CrossrefCASPubMedWeb of Science®Google Scholar Hamberger, A., Chiang, G. H., Sandoval, E., and Cotman, C. W. (1979b) Glutamate as a CNS transmitter. II. Regulation of synthesis in the releasable pool. Brain Res. 168, 531– 541. CrossrefCASPubMedWeb of Science®Google Scholar Hassler, R., Haug, P., Nitsch, C., Kim, J. S., and Paik, K. (1982) Effect of motor and premotor cortex ablation on concentrations of amino acids, monoamines, and acetylcholine and on the ultrastructure in rat striatum. A confirmation of glutamate as the specific cortico-striatal transmitter. J. Neurochem. 38, 1087– 1098. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Henn, F. A. and Hamberger, A. (1971) Glial cell function: uptake of transmitter substances. Proc. Natl. Acad. Sci. USA 68, 2686– 2690. CrossrefCASPubMedWeb of Science®Google Scholar Hertz, L., Bock, E., and Schousboe, A. (1979) GFA content, glutamate uptake and activity of glutamate metabolizing enzymes in differentating mouse astrocytes in primary cultures. Dev. Neurosci. 1, 226– 238. CrossrefWeb of Science®Google Scholar Hokfelt, T. and Ljungdahl, A. (1972) Autoradiographic identification of cerebral and cerebellar cortical neurons accumulating labelled gamma-aminobutyric acid. Exp. Brain Res. 14, 354– 362. CrossrefCASPubMedWeb of Science®Google Scholar Hudson, D. B., Valcana, T., Bean, G., and Timiras, P. S. (1976) Glutamic acid: a strong candidate as the neurotransmitter of the cerebellar granule cell. Neurochem. Res. 1, 83– 92. CrossrefCASPubMedWeb of Science®Google Scholar Jasper, H. H. and Koyama, I. (1969) Rate of release of amino acids from the cerebral cortex in the cat as affected by brain-stem and thalamic stimulation. Can. J. Physiol. Pharmacol. 47, 887– 905. CrossrefGoogle Scholar Johnson, J. L. (1972) An analysis of the activities with the inter-conversion of α-ketoglutarate and glutamate: correlations with free glutamate levels in 20 specific regions in the nervous system. Brain Res. 45, 205– 215. CrossrefCASPubMedWeb of Science®Google Scholar Johnston, G. A. R., Lodge, D., Bornstein, J. C., and Curtis, D. R. (1980) Potentiation of L-glutamate and L-aspartate excitation of cat spinal neurons by the stereoisomers of threo-3--bydroxyaspartate. J. Neurochem. 34, 241– 243. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Kane, E. S. (1979) Central transport and distribution of labelled glutamic and aspartic acids to the cochlear nucleus in cats: an autoradiography study. Neuroscience 4, 729– 745. CrossrefPubMedWeb of Science®Google Scholar Kontro, P., Marnela, K. M., and Oja, S. S. (1980) Free amino acids in the synaptosome and synaptic vesicle fractions of different bovine brain area. Brain Res. 184, 129– 141. CrossrefCASPubMedWeb of Science®Google Scholar Korf, J. and Venema, K. (1983) Amino acids in the substantia nigra of rats with striatal lesions produced by kainic acid. /. Neurochem. 40, 1171– 1173. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Krebs, H. A. (1935) Metabolism of amino acids. IV. Synthesis of glutamine from glutamic acid and ammonia, and the enzymic hydrolysis of glutamine in animal tissue. Biochem. J. 29, 1951– 1969. CrossrefCASPubMedGoogle Scholar Kvamme, E. and Olsen, B. E. (1980) Substrate mediated regulation of phosphate-activated glutaminase in nervous tissue. Brain Res. 181, 228– 233. CrossrefCASPubMedWeb of Science®Google Scholar Lambert, J. D. C., Flatman, J. A., and Engberg, J. (1981) Actions of excitatory amino acids on membrane conductance and potential in motoneurones, in Glutamate as a Neurotransmitter ( G. Chiara and G. L. Gessa, eds), pp. 205– 216. Raven Press, New York . Google Scholar Levi, G., Roberts, P. J., and Raiteri, M. (1976) Release and exchange of neurotransmitters in synaptosomes: effects of the ionophore A23187 and of ouabain. Neurochem. Res. 1, 409– 416. CrossrefPubMedWeb of Science®Google Scholar Levi, G., Gordon, R. D., Gallo, V., Wilkin, G. P., and Balazs, R. (1982) Putative acidic amino acid transmitters in the cerebellum. Brain Res. 239, 425– 445. CrossrefCASPubMedWeb of Science®Google Scholar Logan, W. J. and Snyder, S. H. (1971) Unique high affinity uptake systems for glycine, glutamic and aspartic acids in central nervous tissue of the rat. Nature 234, 297– 299. CrossrefCASPubMedGoogle Scholar Lucas, D. R. and Newhouse, J. P. (1957) The toxic effect of sodium L-glutamate on the inner layers of the retina. Ann. Am. Ophthalmol. 58, 193– 200. CrossrefPubMedWeb of Science®Google Scholar Lund-Karlsen, R. and Fonnum, F. (1976) The toxic effect of sodium glutamate on rat retina: changes in putative transmitters and their corresponding enzymes J. Neurochem. 27, 1437– 1441. Wiley Online LibraryPubMedWeb of Science®Google Scholar Lund-Karlsen, R. and Fonnum, F. (1978) Evidence for glutamate as a neurotransmitter in the corticofugal fibres to the dorsal lateral geniculate body and the superior colliculus in rats. Brain Res. 151, 457– 467. CrossrefPubMedWeb of Science®Google Scholar Machiyama, Y., Balazs, R., Hammond, B. J., Julian, T., and Richer, D. (1970) The metabolism of GABA and glucose in potassium stimulated brain tissue in vitro. Biochem J. 116, 469– 482. CrossrefCASPubMedWeb of Science®Google Scholar Malthe-Sørenssen, D., Skrede, K. K., and Fonnum, F. (1979) Calcium dependent release of D-[3--H]aspartate evoked by selective electrical stimulation of excitatory afferent fibres to hippocampal pyramidal cells in vitro. Neuroscience 4, 1255– 1263. CrossrefCASPubMedWeb of Science®Google Scholar Malthe-Sørenssen, D., Skrede, K. K., and Fonnum, F. (1980) Release of [3H]-D-aspartate from dorso-lateral septum after electrical stimulation of fimbria in vitro. Neuroscience 5, 127– 133. CrossrefCASPubMedWeb of Science®Google Scholar Mangan, S. L. and Whittaker, V. P. (1966) The distribution of free amino acids in suhcellular fractions of guinea-pig brain. Biochem. J. 98, 128– 137. CrossrefCASPubMedWeb of Science®Google Scholar Marc, R. E. and Lam, D. M.W. (1981) Uptake of aspartic and glutamic acid by photoreceptors in goldfish retina. Proc. Natl Acad. Sci. USA 78, 7185– 7189. CrossrefCASPubMedWeb of Science®Google Scholar Mc Bean, G. J. and Roberts, P. J. (1981) Glutamate-preferring receptors regulate the release of D-[3H]aspartate from rat hippocampal slices. Nature 291, 593– 594. CrossrefPubMedWeb of Science®Google Scholar Mc Geer, P. L., Mc Geer, E. G., Scherer, U., and Singh, K. (1977) A glutamergic corticostriatal path Brain Res. 128, 369– 373. CrossrefPubMedWeb of Science®Google Scholar Mc Lennan, H. (1981) On the nature of the receptors for various excitatory amino acids in the mammalian central nervous system. Adv. Biochem. Psychopharmacol. 27, 283– 262. Google Scholar Meister, A. (1979) Biochemistry of glutamate, glutamine and glutathione, in Advances in Biochemistry and Physiology: Glutamic Acid ( S. Keler Garattini, M. R. Kane, W. A. Reynolds, R. J. Wurtman eds), pp. 64– 84. Raven Press, New York . Google Scholar Michaelis, E. W., Michaelis, M. L., Stormann, T. M., Chittenden, W. L., and Grubbs, R. D. (1983) Purification and molecular characterization of the brain synaptic membrane glutamatebinding protein. J. Neurochem. 40, 1742– 1753. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Minchin, M. C. W. and Beart, P. M. (1974) Compartmentation of amino acid metabolism in the rat dorsal ganglia: a metabolic and autoradiographic study. Brain Res. 83, 437– 449. CrossrefWeb of Science®Google Scholar Minchin, M. C. W. and Fonnum, F. (1979) The metabolism of GABA and other amino acids in rat substantia nigra slices following lesions of the striato-nigral pathway. J. Neurochem. 32, 203– 210. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Nadler, J. V. and Smith, E. M. (1981) Perforant path lesion depletes glutamate content of fascia dentata synaptosomes. Neurosci. Lett. 3, 275– 280. CrossrefWeb of Science®Google Scholar Nadler, J. V., White, W. F., Vaca, K. W., Redburn, D. A., and Cotman, C. W. (1977) Characterization of putative amino acid transmitter release from slices of rat dentate gyrus. J. Neurochem. 29, 179– 290. Wiley Online LibraryPubMedWeb of Science®Google Scholar Nadler, J. V., White, W. F., Vaca, K. W., Perry, B. W., and Cotman, C. W. (1978) Biochemical correlates of transmission mediated by glutamate and aspartate. J. Neurochem. 31, 147– 155. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Naito, S. and Ueda, T. (1983) Adenosine triphosphate-dependent uptake of glutamate into protein 1--associated vesicles. J. Biol. Chem. 258, 696– 699. CASPubMedWeb of Science®Google Scholar Nitsch, C., Kim, J.-K., Shimada, Y., and Okada, Y. (1979) Effects of hippocampus extirpation in the rat on glutamate levels in the target structures of hippocampal efferents. Neurosci. Lett. 11, 295– 299. CrossrefCASPubMedWeb of Science®Google Scholar Norenberg, M. D. and Martinez-Hernandez, A. (1979) Fine structural localization of glutamine synthetase in astrocytes of rat brain. Brain Res. 161, 303– 310. CrossrefCASPubMedWeb of Science®Google Scholar Norris, P. J., Smith, C. C. T., de Belleroche, J., Bradford, H. F., Mantle, P. G., Thomas, A. J., and Penny, R. H. C. (1980) Actions of tremorgenic fungal toxins on neurotransmitter release. J. Neurochem. 34, 33– 43. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Oldendorf, W. H. (1971) Brain uptake of radiolabelled amino acids, amines, and hexoses after arterial injection. Am. J. Physiol. 221, 1629– 1639. CASPubMedWeb of Science®Google Scholar Oldendorf, W. H. and Szabo, J. (1976) Amino acid assignment to one of three blood-brain barrier amino acid carriers. Am. J. Physiol. 230, 94– 98. CrossrefCASPubMedWeb of Science®Google Scholar Olney, J. W., Rhee, V., and Ho, O. L. (1974) Kainic acid: A powerful neurotoxic analogue of glutamate. Brain Res. 77, 507– 512. CrossrefCASPubMedWeb of Science®Google Scholar Ottersen, O. P. and Storm-Mathisen, J. (1983) Neurons containing or accumulating transmitter amino acids, in Handbook of Chemical Neuroanatomy, Vol 2 ( A. Bjørklund and T. Hokfelt, eds) (in press). Google Scholar Potashner, S. J. (1978) The spontaneous and electrically evoked release from slices of guinea-pig cerebral cortex of endogenous amino acids labelled via metabolism of D-[U-14] glucose. J. Neurochem. 31, 177– 186. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Pratt, O. E. (1976) The transport of metabolizable substances into the living brain. Adv. Exp. Biol. Med. 69, 55– 75. CrossrefCASPubMedGoogle Scholar Raiteri, M. and Levi, G. (1973) Depletion of synaptosomal neurotransmitter pool by sudden cooling. Nature 243, 180– 182. CASPubMedWeb of Science®Google Scholar Rassin, D. L. (1972) Amino acids as putative transmitters: failure to bind to synaptic vesicles of guinea-pig cerebral cortex. J. Neurochem. 19, 139– 148. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Rea, M. A., Mc Bride, W. J., and Rhode, B. (1980) Regional and synaptosomal levels of amino acid neurotransmitters in 3--acetylpyridine deafferented rat cerebellum. J. Neurochem. 34, 1106– 1108. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Reijnierse, G. L. A., Veldstra, H., and van den Berg, C. J. (1975) Subcellular localization of 7--aminobutyrate transaminase and glutamate dehydrogenase in adult rat brain. Biochem. J. 152, 469– 475. CrossrefCASPubMedWeb of Science®Google Scholar Reubi, J. C. (1980) Comparative study of the release of glutamate and GABA, newly synthesized from glutamine in various regions of the central nervous system. Neuroscience 5, 2145– 2150. CrossrefCASPubMedWeb of Science®Google Scholar Reubi, J. C. and Cuenod, M. (1979) Glutamate release in vitro from cortico-striatal terminals. Brain Res. 176, 185– 188. CrossrefCASPubMedWeb of Science®Google Scholar Reubi, J. C., Toggenburger, G., and Cuenod, M. (1980) Asparagine as precursor for transmitter aspartate in corticostriatal fibres. J. Neurochem. 35, 1015– 1017. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Roberts, E. and Frankel, D. (1950) 7--Aminobutyric acid in brain: its formation from glutamic acid. J. Biol. Chem. 187, 55– 63. CASPubMedWeb of Science®Google Scholar Roberts, P. J. and Watkins, J. C. (1975) Structural requirements for the inhibition of L-glutamate uptake by glia and nerve endings. Brain Res. 85, 120– 125. CrossrefCASPubMedWeb of Science®Google Scholar Roberts, P. J., Storm-Mathisen, J., and Johnston, G. A. R. (1981) Glutamate Transmitter in the Central Nervous System. John Wiley & Sons, Chichester . Google Scholar Rohde, B. H., Rea, M. A., Simon, J. R., and Mc Bride, W. J. (1979) Effects of X-irradiation-induced loss of cerebellar granule cells on synaptosomal levels and the high affinity uptake of amino acids. J. Neurochem. 32, 1431– 1435. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Rowlands, G. J. and Roberts, P. J. (1980) Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract. Exp. Brain Res. 39, 239– 240. CrossrefCASPubMedWeb of Science®Google Scholar Rustioni, A. and Cuenod, M. (1982) Selective retrograde transport of D-aspartate in spinal interneurons and cortical neurons of rats. Brain Res. 236, 143– 155. CrossrefCASPubMedWeb of Science®Google Scholar Rustioni, A., Spreafico, R., Cheema, S., and Cuenod, M. (1982) Selective retrograde labelling of somatosensory cortical neurons after 3H-D-aspartate injections in the ventrobasal complex of rats and cats. Neuroscience (Suppl.) 7, S183. Google Scholar Sandoval, M. E. and Cotman, C. W. (1978) Evalution of glutamate as a neurotransmitter of cerebellar fibres. Neuroscience 3, 199– 206. CrossrefCASPubMedWeb of Science®Google Scholar Schon, F. and Kelly, J. S. (1974) Autoradiographic localization of [3H]-GABA and [3H]-glutamate over satellite glial cells. Brain Res. 66, 275– 288. CrossrefCASGoogle Scholar Sellström, A. and Hamberger, A. (1977) Potassium-stimulated γ-aminobutyric acid release from neurons and glia. Brain Res. 119, 189– 198. CrossrefCASPubMedWeb of Science®Google Scholar Shank, R. P. and Campbell Lem. (1982) Glutamine and alphaketoglutarate uptake and metabolism by nerve terminal enriched material from mouse cerebellum. Neurochem. Res. 7, 601– 616. CrossrefCASPubMedWeb of Science®Google Scholar Shank, R. P. and Campbell Lem. (1983) Amino acid uptake, content and metabolism by neuronal and glial enriched cellular fractions from mouse cerebellum. J. Neurosci (in press). Google Scholar Sharif, N. A. and Roberts, P. J. (1981) L-Aspartate binding sites in rat cerebellum: a comparison of the binding of L-[3H]aspartate and L-[3H]glutamate to synaptic membranes. Brain Res. 211, 293– 303. CrossrefCASPubMedWeb of Science®Google Scholar Skrede, K. K. and Malthe-Sørenssen, D. (1981) Differential release of D-[3H]aspartate and [14C]-γ-aminobutyric acid following activation of commissural fibres in a longitudinal slice preparation of guinea-pig hippocampus. Neurosci. Lett. 21, 71– 76. CrossrefCASPubMedWeb of Science®Google Scholar Smith, C. C. T., Bradford, H. F., Thompson, E. J., and MacDermot, J. (1980) Actions of β-bungarotoxin on amino acid transmitter release. J. Neurochem. 34, 487– 494. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Søreide, A. and Fonnum, F. (1980) High affinity uptake of D-[3H]aspartate in the barrel subfield of the mouse somatic sensory cortex. Brain Res. 201, 727– 730. CrossrefWeb of Science®Google Scholar Spencer, H. J. (1976) Antagonism of cortical excitation of striatal neurons by glutamic acid diethylester: evidence for glutamic acid as an excitatory transmitter in the rat striatum. Brain Res. 102, 91– 101. CrossrefCASPubMedWeb of Science®Google Scholar Stallcup, W. B., Bulloch, K., and Baetge, E. E. (1979) Coupled transport of glutamate and sodium in cerebellar nerve cell line. J. Neurochem. 32, 57– 65. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Stone, T. W. (1979) Amino acids as neurotransmitters of corti-cofugal neurons in the rat: a comparison of glutamate and aspartate. Br. J. Pharmacol. 67, 545– 551. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Storm-Mathisen, J. (1977) Glutamic acid and excitatory nerve endings: reduction of glutamic acid uptake after axotomy. Brain Res. 120, 379– 386. CrossrefCASPubMedWeb of Science®Google Scholar Storm-Mathisen, J. and Iversen, L. L. (1979) Uptake of [3H]-glutamic acid in excitatory nerve endings. Light and electron-microscopic observations in the hippocampal formation of the rat. Neuroscience 4, 1237– 1253. CrossrefCASPubMedWeb of Science®Google Scholar Storm-Mathisen, J. and Woxen-Opsahl, M. (1978) Aspartate and/ or glutamate may be transmitters in hippocampal efferents to septum and hypothalamus. Neurosci. Lett. 9, 65– 70. CrossrefCASPubMedWeb of Science®Google Scholar Storm-Mathisen, J., Leknes, A. K., Bore, A. T., Vaaland, J. L., Edminson, P., Haug, F. M.-S., and Ottersen, O. P. (1983) Glutamate and GABA: first visualization in neurones by immunocytochemistry. Nature 301, 517– 520. CrossrefCASPubMedWeb of Science®Google Scholar Streit, P. (1980) Selective retrograde labeling indicating the trans mitter of neuronal pathways. J. Comp. Neurol. 191, 429– 463. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Talman, W. T., Perrone, M. H., and Reis, D. J. (1980) Evidence of glutamate as a neurotransmitter of baroreceptor afferent nerve fibres. Science 209, 813– 815. CrossrefCASPubMedWeb of Science®Google Scholar Thangnipon, W., Taxt, T., Brodal, P., and Storm-Mathisen, J. (1983) The corticopontine projection: axotomy-induced loss of high affinity L-glutamate and D-aspartate uptake, but not of gamma-aminobutyrate uptake, glutamate decarboxylase or choline acetyltransferase, in the pontine nuclei. Neuroscience 8, 449– 457. CrossrefCASPubMedWeb of Science®Google Scholar Thanki, C. M., Sugden, D., Thomas, N. J., and Bradford, H. F. (1983) In vivo release from cerebral cortex of [14C]glutamate synthesized from [U-14C]glutamine. J. Neurochem. 41, 611– 617. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Toggenburger, G., Felix, D., Cuenod, M., and Henke, H. (1982) In vitro release of endogenous beta-alanine, GABA and glutamate, and electrophysiological effect of beta-alanine in pigeon optic tectum. J. Neurochem. 39, 176– 183. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Usherwood, P. N. R. (1981) Glutamate synapses and receptors in insect muscle, in Glutamate as a Neurotransmitter ( G. Di-Chiara and G. L. Gessal, eds), pp 183– 192. Raven Press, New York . Google Scholar van den Berg, C. J. (1973) A model of compartrnentation in mouse brain based on glucose and acetate metabolism, in Metabolic Compartmentation in the Brain ( R. Balazs and J. E. Cremer, eds), pp. 137– 166. Macmillan, New York . CrossrefWeb of Science®Google Scholar van den Berg, C. J., Matheson, D. F., Ronda, G., Reijnierse, G. L. A., Blokhuis, G. G. D., Kroon, M. C., Clarke, D. D., and Garfinkel, D. (1975) A model of glutamate metabolism in brain: a biochemical analysis of a heterogenous structure, in Metabolic Compartmentation and Neurotransmission ( S. Berl, D. D. Clarke, and D. Schneider, eds), pp. 709– 723. Plenum Press, New York . Google Scholar Vincent, S. R. and Mc Geer, E. G. (1980) A comparison of sodium dependent glutamate binding with high affinity glutamate uptake in rat striatum. Brain Res. 184, 99– 105. CrossrefCASPubMedWeb of Science®Google Scholar Walaas, I. (1981) Biochemical evidence for overlapping neocor-tical and allocortical glutamate projections to the nucleus accumbens and rostral caudatoputamen in the rat brain. Neuroscience 6, 399– 406. CrossrefCASPubMedWeb of Science®Google Scholar Walaas, I. and Fonnum, F. (1979) The effects of surgical and chemical lesions on neurotransmitter candidates in the nucleus accumbens of the rat. Neuroscience 4, 209– 216. CrossrefCASPubMedWeb of Science®Google Scholar Walaas, I. and Fonnum, F. (1980) Biochemical evidence for glutamate as a transmitter in hippocampal efferents to the basal forebrain and hypothalamus in rat brain. Neuroscience 5, 1691– 1698. CrossrefCASPubMedWeb of Science®Google Scholar Walker, J. and Fonnum, F. (1983) Regional cortical glutamergic and aspartergic projections to the amygdala and thalamus of the rat. Brain Res. 267, 371– 374. CrossrefCASPubMedWeb of Science®Google Scholar Waniewski, R. A. and Martin, D. L. (1983) Selective inhibition of glial versus neuronal uptake of L-glutamic acid by SITS. Brain Res. 268, 390– 394. CrossrefCASPubMedWeb of Science®Google Scholar Ward, H. W., Thanki, C. M., Peterson, D. W., and Bradford, H. F. (1982) Brain glutaminase activity in relation to transmitter glutamate biosynthesis. Biochem. Soc. Trans. 10, 369– 370. Google Scholar Ward, H. W., Thanki, C. M., and Bradford, H. F. (1983) Glutamine and glucose as precursors of transmitter amino acids: ex vivo studies. J. Neurochem. 40, 855– 860. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Watkins, J. C. (1981) Pharmacology of excitatory amino acid receptors, in Glutamate: Transmitter in the Central Nervous System ( P. J. Roberts, J. Storm-Mathisen, and G. A. R. Johnston, eds), pp. 1– 24. John Wiley & Sons, Chichester . Google Scholar Weil-Malherbe, H. (1950) Significance of glutamic acid for the metabolism of nervous tissue. Physiol. Rev. 30, 549– 568. CrossrefCASPubMedWeb of Science®Google Scholar Wenthold, R. J. (1978) Glutamic acid and aspartic acid in subdivisions of the cochlear nucleus after auditory nerve lesion. Brain Res. 143, 544– 548. CrossrefCASPubMedWeb of Science®Google Scholar Wenthold, R. J. (1979) Release of endogenous glutamic acid, aspartic acid and GABA from cochlear nucleus slices. Brain Res. 162, 338– 343. CrossrefCASPubMedWeb of Science®Google Scholar Wenthold, R. J. (1980) Glutaminase and aspartate amino trans-ferase decrease in cochlear nucleus after lesion of the auditory. Brain Res. 190, 283– 297. CrossrefWeb of Science®Google Scholar Wheeler, D. D. and Hollingsworth, R. G. (1978) A model of high affinity glutamic acid transport by cortical synaptosomes from the Long-Evans rat. J. Neurochem. 30, 1311– 1319. Wiley Online LibraryCASPubMedWeb of Science®Google Scholar Wieraszko, A. and Lynch, G. (1979) Stimulation dependent release of possible transmitter substances from hippocampal slices studied with localized perfusion. Brain Res. 160, 372– 376. CrossrefCASPubMedWeb of Science®Google Scholar Wiklund, L., Toggenburger, G., and Cuenod, M. (1982) Aspartate: possible neurotransmitter in cerebellar climbing fibers. Science 216, 78– 80. CrossrefCASPubMedWeb of Science®Google Scholar Wilkins, G. P., Garthwaite, J., and Balazs, R. (1982) Putative amino acid transmitters in the cerebellum. II. Electron microscopic localization of transport sites. Brain Res. 244, 69– 80. CrossrefPubMedWeb of Science®Google Scholar Yoneda, Y., Roberts, E., and Dietz Young, A. B., Oster-Granite, M. L., Herndon, R. M., and Snyder, S. H. (1974) Glutamic acid: selective depletion by viral induced granule cell loss in hamster cerebellum. Brain Res. 73, 1– 13. CrossrefPubMedGoogle Scholar Young, A. B., Bromberg, M. B., and Penny, J. B. (1981) Decreased glutamate in subcortical areas deafferented by sensorimotor cortex ablation in the cat. J. Neurosci. 1, 241– 249. CASPubMedWeb of Science®Google Scholar Citing Literature Volume42, Issue1January 1984Pages 1-11 ReferencesRelatedInformation