Graph-based Biomedical Knowledge Discovery

The digitalization process is progressing at a very high speed all over the world. While this situation provides many conveniences in today’s life, it also brings along a problem such as analyzing and processing the huge digital data. This also applies to published academic studies. In this sense, the process of evaluating each study to access previously unknown information within the studies requires a very laborious process. For this reason, in this study, the publications obtained for the target diseases were analyzed by text analysis processes and converted into a graph structure that enables the linking of meaningful terms through biomedical relationships. On the dense graph structure obtained, binary biomedical entities with important links such as treats, causes, associated_with were queried. The entity pairs obtained according to the query results were also confirmed by manual search method and proved to be real connections. In this study, retrieval of known biomedical entities with the proposed approach solved the time-consuming manual search problem. There is also the potential to obtain unknown/unexplored possible new relationships (e.g., therapeutic, causal, etc.) with multiple binary linking patterns.