Background: Despite the globally acclaimed efficacy of the ICD-10 as a tool for disease classification, existing evidence focus on quality of disease coding outcomes with limited evidence on determinants of utilization. The starting point to sustaining the quality of disease coding is establishing its utilization and its determinants. There is paucity of evidence on role of health professional factors on use of ICD systems in Kenya. Objective: To determine health professionals' factors associated with utilization of ICD-10 in Public Hospitals. Methods: This study was conducted in Kiambu County, Kenya among public health facilities. Cross-sectional descriptive study design was used. A total of 46 health records and information officers [HRIOs] were sampled using total population sampling. Data was collected using self-administered questionnaires. Descriptive statistics, chi-square and regression analysis was used to analyse and synthesis the data using SPSS version 22. Results: Out of the 42 respondents, 28 (67%) indicated that the systems were utilized either frequently or always. Chi-square analysis revealed that ICD perception was the only health professional factor significantly associated with ICD-10 utilization. Positive perception of ICD-10 utility increased the likelihood of its frequent use by approximately 4.63 times (OR = 4.63; p=0.049). Conclusion: Staff perception of ICD systems is an important determinant of its utilization. Providing tailored capacity building and sensitization of ICD system benefits and value-add to staff can significantly counter negative perceptions and improve utilization in hospitals.