Результаты Применения Рамуцирумаба В Монорежиме Или В Комбинации С Паклитакселом Во Второй Линии Лечения Больных Диссеминированной HER2-негативной Аденокарциномой Желудка Или Кардиоэзофагеального Перехода. Опыт Национального Медицинского Исследовательского Центра Онкологии Им. Н.Н. Блохина

Background. Working out of the second line chemotherapy of advanced gastric adenocarcinoma is a promising approach to cancer therapy. Ramucirumab, an anti-angiogenic agent specifically targeting vascular endothelial growth factor receptor-2 (VEGFR-2). In April 2014, the FDA approved ramucirumab as a single agent or in combination with paclitaxel for treatment of advanced gastric or gastroesophageal junction adenocarcinoma that has progressed on or after prior fluoropyrimidineor platinum containing chemotherapy based on data of REGARD and RAINBOW trials. Materials and Methods : From June 2016 to 15Jan 201837 pts with advanced GC were treated with ramucirumabin the second line treatment as single agent (11 pts) or in combination with paclitaxel (26 pts) in N.N.Blokhin National medical research center of oncology. Results : edian PFS (MPFS) and median OS (MOS) was 1,8 and 7,6 mons for monotherapy group. For combination group MPFS was 4,0mons, MOS -10,6 mons. Ramucirumab had an acceptable safety profile Conclusions :ur data are similar to the data of international randomized trials.