Hijacked on Arrival: Glucocorticoids Enable Disseminated Tumor Cell Immune Evasion.

Upon leaving the protective microenvironment of the primary tumor, disseminating tumor cells (DTCs) must withstand immune surveillance on their own. Cassandras et al. recently demonstrated that activation of the glucocorticoid receptor pathway serves as a critical mechanism for immune evasion during metastatic outgrowth from DTCs.