Human Cytomegalovirus Induces Apoptosis in Neural Stem/progenitor Cells Derived from Induced Pluripotent Stem Cells by Generating Mitochondrial Dysfunction and Endoplasmic Reticulum Stress

Congenital human cytomegalovirus (HCMV) infection, a leading cause of birth defects, is most often manifested as neurological disorders. The pathogenesis of HCMV-induced neurological disorders is, however, largely unresolved, primarily because of limited availability of model systems to analyze the effects of HCMV infection on neural cells.