Introduction: Hypertrophic and polyposis SM changes in patients with BA and AR negatively affect the course of these diseases. The features of systemic immune regulation in these patients remain unknown. Purpose of the study: To study the relationship of hypertrophic and polyposis SM changes with the content of serum immunoglobulins A, M, G and E. Methods: We examined 137 patients with atopic BA and AR at the age of 10.0 [7.0; 13.0] years, of which boys - 75.2% (103/137). Determination of the content of total IgE, as well as IgA, IgM, IgG in the blood serum was carried out by the enzyme-linked immunosorbent method. Results: In 19.7% (27/137) children, SM changes were revealed in the form of local hypertrophy of the medial surface of the turbinates, in 10.9% (15/137) polyposis SM changes. The content of serum total IgE was comparable in children with the absence and presence of synonasal hypertrophy (p = 0.65), as well as in serum Ig M (p = 0.74). At the same time, the serum IgA content in children with synonasal hypertrophy unexpectedly turned out to be statistically significantly higher (p = 0.024), and the serum IgG content had a clear tendency to increase (p = 0.053) compared with children who did not have hypertrophic SM changes. Conclusions: Children with hypertrophic and polyposis changes in SM showed a statistically significantly higher level of total serum IgA compared with children without SM hypertrophy. Apparently, BA and AR patients with hypertrophic SM changes have a unique systemic immunological profile that requires serious study.
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