Background& Objectives: Hypochlorous acid (HOCl) is a safe antimicrobi aleffective for wound care in areas burdened by chronic infections such as mycetoma. Its broad antimicrobial activity, biofilm disruption, and exceptional tissue compatibility make it well-suited for the long-term management of complex wounds. In mycetoma-endemic regions, HOCl offers a practical assistant for infection control and improved wound healing, providing a low-cost option for strengthening community-level care. Methods: This preliminary field-based humanitarian effectiveness, observational study evaluated the topical application of HOCl on seven patients with mycetoma lesions in Wad Shigidi Village, Sudan. The HOCl intervention was adjunctive and topical, not systemic. Weekly field visits were conducted, and lesion responses were documented using photographic and clinical criteria. Results: Patients demonstrated marked reductions in lesion size, discharge, and pain. No adverse effects were reported. Interpretation & Conclusions: HOCl shows promise as a safe, low-cost topical agent for mycetoma and other wound care at the community level in humanitarian settings. Further studies are warranted.
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