Identification of a Rhodium(iii) Complex As a Wee1 Inhibitor Againsttp53-Mutated Triple-Negative Breast Cancer Cells

The rhodium(iii) complex 1 was identified as a potent Wee1 inhibitor in vitro and in cellulo. It decreased Wee1 activity and unscheduled mitotic entry, and induced cell damage and death in TP53-mutated triple-negative breast cancer cells. 1 represents a promising scaffold for further development of more potent metal-based Wee1 antagonists.