Инкапсулирование Доксорубицина В Липосомы, Содержащие Фосфатидилэтанол. III. Влияние На Токсичность И Накопление Антибиотика В Миокарде

The toxicity of sterically stabilized doxorubicin-containing "solid" liposomes comprising a mixture of distearoyl analogs of phospatidylcholine and phosphatidylethanol (in a 3 : 2 molar ratio) was evaluated. Upon injection of the ordinary and liposomal doxorubicin in a total dose of 12 mg/kg, the early loss of mice with implanted ascitic Ehrlich's carcinoma was 100 and 50%, respectively, and the average lifetime of the animals treated with liposomal doxorubicin was 1.6 times longer. In comparison to the ordinary doxorubicin, injections of the liposomal preparation resulted in a lower drop of the body weight (10%) and a smaller decrease in leukocyte number (12%). The results of fluorimetric measurements showed that the accumulation of antibiotic in the cardiac muscle 15 - 180 min after injection of liposomal doxorubicin was 30 - 57% lower than that upon the injection of the ordinary preparation.