In Response to the Article Published by Dewolf Et Al, Entitled: "effect of Walking Speed on the Intersegmental Coordination of Lower-Limb Segments in Elderly Adults", Gait & Posture (2019).

Level Walking is a frequent functional movement during daily life. However, sloped walking is also common. Exploring 6DOF knee kinematics during sloped walking is important. It provides a reference for the rehabilitation, safety, and knee health of patients with knee diseases walking on sloped surfaces.The study aimed to explore 6DOF knee kinematics characteristics during sloped walking compared to level walking. We hypothesized that tibial anteroposterior translation and flexion angle (the sagittal plane) were significantly different from those of level walking.One hundred young, healthy adults (50 males and 50 females) were recruited for this study. A three-dimensional gait analysis system was used to collect 6DOF knee kinematics during level and sloped walking. The slope was set to ± 15% when the sloped walking was performed.Sloped walking mainly increased knee flexion angle (upslope, 2.5–26.2°, 1–100% gait cycle (GC), p < 0.05; downslope, 1.7–11.9°, 15–95% GC, p < 0.05) and anterior tibial translation (upslope, 0.7–4.1 mm, 3–54% GC & 0.6–2.1 mm, 80–94% GC; downslope, 1.0–2.2 mm, 21–69% GC) in the participants' knees. However, participants' other 4DOF knee kinematics during sloped walking were significantly different from those during level walking (p < 0.05). Participants had 'drastically changeable' knee kinematic alterations in the transverse and coronal plane (the other 4DOF knee kinematics) during sloped walking compared to level walking.Our results confirmed the hypothesis. Sloped walking significantly increased anterior tibial translation (in most GC) and flexion angle. These kinematic changes in healthy subjects should be evaluated and further explored for patients with knee diseases, such as anterior cruciate ligament deficiency. Our findings are meaningful for their rehabilitation or safety or knee health while walking on sloped surfaces. Our study may provide a pilot reference for the 6DOF knee kinematic exploration of sloped walking.