Integration of Polygenic Risk Score with Measured Blood Pressure Reveals Hidden Risks of Cardiovascular Disease Mortality: A Japanese Prospective Cohort Study

Although previous studies reported that BP PRS is associated with CVD, it is less explored whether BP PRS and BP are jointly associated with CVD, especially among non-European populations. Therefore, we examined joint associations of BP control and BP polygenic risk score (PRS) with CVD mortality in a Japanese population. Data were obtained from the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study, the multi-centered cohort study with 14 study areas throughout Japan. Of which, we analyzed 35,000 Japanese individuals (Mean age: 55 years old, Men: 44