Intergenerational stress (IGS) is the transfer of the physiological and behavioral consequences of stress from one generation to the next. Data suggest that IGS could amplify the risk for psychiatric disorders in offspring. Herein we sought to identify some of the neurobiological bases of IGS by applying a whole brain analytic approach to resting state fMRI data collected from mother-child dyads, which could be the basis for the development of novel, brain-targeted prevention strategies for childhood psychiatric disorders.
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