JAMA Patient Page. Chronic Obstructive Pulmonary Disease.

Chronic Obstructive Pulmonary DiseaseC hronic obstructive pulmonary disease (COPD) is a term used to describe 2 related lung diseases: chronic bronchitis and emphysema.Chronic bronchitis is inflammation and eventual scarring of the bronchi (airway tubes).Emphysema is enlargement and destruction of the alveoli (air sacs) within the lungs.Many persons with COPD have both of these conditions.Persons with COPD have difficulty breathing because they develop smaller air passageways and have partially destroyed alveoli.The air passageways also become clogged with mucus, a slimy substance.Smoking cigarettes is the most important risk factor and cause of COPD.About 80% to 90% of COPD cases are caused by smoking, and a smoker is 10 times more likely than a nonsmoker to die of COPD.The November 5, 2003, issue of JAMA includes an article about treatments for COPD.