Background Chronic diseases remain a predominant cause of mortality worldwide despite existing therapies, which often have side effects and high costs. Natural compounds, such as kavain from Piper methysticum, have attracted attention for their therapeutic potential and safety, showing diverse biological activities useful in treating various health conditions. Purpose This study aimed to assess the potential role of kavain in the prevention and treatment of chronic diseases, with a particular focus on its anti-inflammatory, anxiolytic, antithrombotic, neuroprotective, and anticancer properties. Method A comprehensive literature search on kavain was conducted using PubMed, Scopus, Science direct and Web of Science databases, considering both preclinical and clinical studies. The term “kavain” was used, and all titles, abstracts, and keywords were screened for relevant information. Results Findings from various experimental models suggest that kavain exhibits significant biological and pharmacological activities across various pathological conditions, including inflammation, anxiety, neurological disorders, cardiovascular diseases, and cancer. Pharmacokinetic studies reveal its rapid absorption, moderate oral bioavailability, and efficient systemic clearance. Mechanistically, kavain regulates various molecular pathways including nuclear factor-κB and mitogen-activated protein kinase signaling, modulation of γ-aminobutyric acid type A receptor activity, and inhibition of osteoclastogenesis. Toxicity studies indicate that kavain is well-tolerated at physiologically relevant concentrations. Clinical reports show its anxiolytic potential with favorable safety profile. Conclusion Kavain has demonstrated considerable therapeutic potential in the prevention and management of various chronic diseases, with relatively few adverse effects. Consequently, further clinical investigations will be beneficial to validate its efficacy and safety in human populations.
更多
原文链接
分享
引用
