KNOWLEDGE-BASED ORCHESTRATION OF PROTEIN SEQUENCE ANALYSIS AND KNOWLEDGE ACQUISITION FOR PROTEIN STRUCTI . JRE PREDICTION

The goal of this research is !o produce more effective methods for protein sequence analysis and strucure prediction through the rse of krnwledge-based techniques for orchestrating protein sequerce and other analyses. We are developing a system (PAPAIN) that will provide intelligent assistance in manipulating and integrating diverse sources of information in a manner ttrat will permit experimentation with hypothesis formation and reasoning styles. This paper describes foundational knowledge engineering studies, ttre resulting logical simuliuion and outlines curent research.