Locomotion in Vertebrates: Central Mechanisms and Reflex Interaction.

articleLocomotion in vertebrates: central mechanisms and reflex interactionS. GrillnerS. GrillnerPublished Online:01 Apr 1975https://doi.org/10.1152/physrev.1975.55.2.247MoreSectionsPDF (8 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByLocomotor pattern generation and descending control: a historical perspectiveRéjean Dubuc, Jean-Marie Cabelguen†, andDimitri Ryczko16 August 2023 | Journal of Neurophysiology, Vol. 130, No. 2Joint-level coordination patterns for split-belt walking across different speed ratiosRobert E. Kambic, Ryan T. Roemmich, andAmy J. Bastian18 April 2023 | Journal of Neurophysiology, Vol. 129, No. 5Epidural spinal cord stimulation as an intervention for motor recovery after motor complete spinal cord injuryJan T. Hachmann, Andrew Yousak, Josephine J. Wallner, Parag N. Gad, V. Reggie Edgerton, andAshraf S. 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II. 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II. Regional developmentDevelopmental Brain Research, Vol. 11, No. 1Postural supporting mechanisms during spontaneous single limb movement in the catNeuroscience Letters, Vol. 40, No. 2Fetal locus coeruleus transplanted into the transected spinal cord of the adult ratBrain Research, Vol. 271, No. 1Initiation and sensory gating of ‘fictive’ swimming and withdrawal responses in an in vitro preparation of the lamprey spinal cordBrain Research, Vol. 269, No. 2On the Space-Time Structure of Human Interlimb Co-Ordination1 January 2018 | The Quarterly Journal of Experimental Psychology Section A, Vol. 35, No. 2Development of catecholaminergic nerves in the spinal cord of the ratBrain Research, Vol. 264, No. 2Physiology and pharmacology of putative transmitters in lamprey central nervous systemProgress in Neurobiology, Vol. 20, No. 3-4Connections of the mesencephalic locomotor region (MLR) I. 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Effects of dopaminergic drugs and electric stimulation of the brainstemJournal of Neuroscience Methods, Vol. 6, No. 1-2Behavioural and neurochemical effects of intracerebroventricular administrations ofp-octopamine in ratsBrain Research, Vol. 241, No. 2Polarization of primary afferent terminals of lumbosacral cord elicited by the activity of spinal locomotor generatorNeuroscience, Vol. 7, No. 6EMG activity and kinematics of human cycling movements at different constant velocitiesBrain Research, Vol. 240, No. 2Induction of hindlimb stepping movements in rats spinally transected as adults or as neonatesBrain Research, Vol. 240, No. 2Effects of ibotenic acid-induced neuronal degeneration in the medial preoptic area and the lateral hypothalamic area on sexual behavior in the male ratBrain Research, Vol. 239, No. 1Pathophysiology of gait in children with cerebral palsyElectroencephalography and Clinical Neurophysiology, Vol. 53, No. 5Development and maintenance of dendrite bundles after cordotomy in exercised and nonexercised catsExperimental Neurology, Vol. 76, No. 2Adrenergic receptors in rat spinal cordNeuropharmacology, Vol. 21, No. 2The nature of the coupling between segmental oscillators of the lamprey spinal generator for locomotion: A mathematical modelJournal of Mathematical Biology, Vol. 13, No. 3Control theories in motor behaviorActa Psychologica, Vol. 50, No. 1Development of β-adrenergic receptors and the in vitro accumulation of cyclic AMP in the chick spinal cordDevelopmental Brain Research, Vol. 3, No. 1Induction of swimming in the high spinal stingray by L-DOPABrain Research, Vol. 220, No. 1Sensory interactions with a central motor program in anuran larvaeBrain Research, Vol. 218, No. 1-2Model for the Continuous Description of Motion and Position19 October 2016 | Perceptual and Motor Skills, Vol. 53, No. 1The effect of 4-aminopyridine on the spinal locomotor rhythm induced byl-DOPABrain Research, Vol. 215, No. 1-2Locomotion elicited by pinna stimulation in the acute precollicular-post- mammillary decerebrate catBrain Research, Vol. 214, No. 2Divergent projections of catecholamine neurons of the locus coeruleus as revealed by fluorescent retrograde double labeling techniqueNeuroscience Letters, Vol. 23, No. 2Reflex and locomotor changes following unilateral deafferentation of rat hind limb assessed by chronic electromyographyNeuroscience, Vol. 6, No. 2Control of rhythmic behaviour by a hierarchy of linked oscillators in crustaceaNeuroscience Letters, Vol. 21, No. 1A silent period in sural muscle occurring prior to the voluntary forward inclination of the bodyNeuroscience Letters, Vol. 21, No. 2Responses of long descending propriospinal neurons to natural and electrical types of stimuli in catBrain Research, Vol. 196, No. 2Central and peripheral controls of swimming in anuran larvaeBrain Research, Vol. 195, No. 2Cyclic AMP formation in rat spinal cord tissue slicesNeuropharmacology, Vol. 19, No. 7Recovery of substance P in the cat spinal cord after unilateral lumbosacral deafferentationBrain Research, Vol. 191, No. 2On the interaction between spinal locomotor generators in quadrupedsBrain Research Reviews, Vol. 2, No. 1-3Descending projections of the locus coeruleus and subcoeruleus/medial parabrachial nuclei in monkey: Axonal transport studies and dopamine-β-hydroxylase immunocytochemistryBrain Research Reviews, Vol. 2, No. 1-3Inhibition of flexor burst generation by loading ankle extensor muscles in walking catsBrain Research, Vol. 187, No. 2Main characteristics of the hindlimb locomotor cycle in the decorticate cat with special reference to bifunctional musclesBrain Research, Vol. 187, No. 2Effect of noradrenaline and 5-hydroxytryptamine depletion on locomotion in the catBrain Research, Vol. 185, No. 2Compensation for substrate elasticity in the kinematics of leaping by infant pigtailed macaques (Macaca nemestrina)Brain Research, Vol. 184, No. 2Motorneuronal control of locomotion in AplysiaBrain Research, Vol. 179, No. 2Effects of stimulalating Deiters' nucleus and memdial longitudinal fasciculus on the timing of the fictive locomotor rhythm induced in cats by DOPABrain Research, Vol. 177, No. 3Locomotion evoked by brain stem stimulation: occurrence without phasic segmental afferent inputBrain Research, Vol. 177, No. 1Locomotion in the decerebrate stingrayNeuroscience Letters, Vol. 14, No. 2-3Hippocampal EEG and behaviour in dog. I. Hippocampal EEG correlates of gross motor behaviourElectroencephalography and Clinical Neurophysiology, Vol. 46, No. 5Experimental modification of interlimb coordination during locomotion of a crustaceaNeuroscience Letters, Vol. 12, No. 2-3The adaptation to speed in human locomotionBrain Research, Vol. 165, No. 1Relationship between forelimb coordination and movement asymmetries during fast gaits, canter and gallopBrain Research, Vol. 164, No. 1-2Spontaneous respiratory activity in spinal catsBrain Research, Vol. 157, No. 2Central locomotor program for the cat's hindlimbNeuroscience, Vol. 3, No. 11Evidence for distinct spinal locomotion generators supplying respectively fore- and hindlimbs in the rabbitBrain Research, Vol. 155, No. 1Messages conveyed by spinocerebellar pathways during scratching in the cat. I. Activity of neurons of the lateral reticular nucleusBrain Research, Vol. 151, No. 3Peripheral control of the spinal pattern generators for locomotion in catBrain Research, Vol. 150, No. 3Unitary activity of ventrolateral nucleus during placing movement and associated postural adjustmentBrain Research, Vol. 149, No. 2Postural and kinetic coordination following cortical stimuli which induce flexion movements in the cat's limbsBrain Research, Vol. 149, No. 1Locomotory programs in basal leg muscles after limb autotomy in the crustaceaBrain Research, Vol. 145, No. 2Functional organization of the spinal reflex pathways from forelimb afferents to hindlimb motoneurones in the catBrain Research, Vol. 139, No. 1Effects of midbrain tegmentum and diencephalon lesions on swimming and body orientation in goldfishExperimental Neurology, Vol. 57, No. 3Expression of magnus tonic neck reflexes in distal muscles of prehension in normal adultsPhysiology & Behavior, Vol. 19, No. 4A new major projection from locus coeruleus: The main source of noradrenergic nerve terminals in the ventral and dorsal columns of the spinal cordBrain Research, Vol. 132, No. 1Phasic gain control of reflexes from the dorsum of the paw during spinal locomotionBrain Research, Vol. 132, No. 1Relationship between residual hindlimb-assisted locomotion and surviving axons after incomplete spinal cord injuriesExperimental Neurology, Vol. 56, No. 2Is there a peripheral control of the central pattern generators for swimming in dogfish?Brain Research, Vol. 127, No. 2Locomotor recovery after unilateral hindlimb deafferentation in catsBrain Research, Vol. 123, No. 1The control of arthropod walkingComparative Biochemistry and Physiology Part A: Physiology, Vol. 56, No. 2Neuronal events underlying rhythmic behaviors in invertebratesComparative Biochemistry and Physiology Part A: Physiology, Vol. 57, No. 2Development of locomotor activities in young chronic spinal rabbitsNeuroscience Letters, Vol. 3, No. 5-6On spinal noradrenaline receptor supersensitivity: Correlation between nerve terminal densities and flexor reflexes various times after intracisternal 6-hydroxydopamineBrain Research, Vol. 116, No. 3Effet de l'ablation du cortex moteur ou du cervelet sur la coordination posturo-cinetique chez le chatElectroencephalography and Clinical Neurophysiology, Vol. 41, No. 4Central generation of locomotion in the spinal dogfishBrain Research, Vol. 109, No. 2Coordinated stepping of all four limbs in the high spinal catBrain Research, Vol. 109, No. 2Ensemble characterivstics ofcat locovmotionand its neural controlProgress in Neurobiology, Vol. 7Locomotion in the cat: Basic programmes of movementBrain Research, Vol. 91, No. 2How detailed is the central pattern generation for locomotion?Brain Research, Vol. 88, No. 2Phase dependent reflex reversal during walking in chronic spinal catsBrain Research, Vol. 85, No. 1Biological motor control approaches for a planar diverEnergy-based pattern transition in quadrupedal locomotion with oscillator and mechanical modelA mathematical model of adaptation in rhythmic motion to environmental changesA neural pattern generator that tunes into the physical dynamics of the limb systemAutonomous decentralized system with self-organizing function and its application to generation of locomotive patternsGait Transition Control of a Biped Robot from Quadrupedal to Bipedal Locomotion Based on Central Pattern Generator, Phase Resetting, and Kinematic SynergyGait Generation and Transition of a Biped Robot Based on Kinematic Synergy in Human Locomotion More from this issue > Volume 55Issue 2April 1975Pages 247-304 Copyright & PermissionsCopyright © 1975 the American Physiological Societyhttps://doi.org/10.1152/physrev.1975.55.2.247PubMed1144530History Published online 1 April 1975 Published in print 1 April 1975 Metrics