In this paper, few models are proposed, in which the flow distribution and transfer of heat of proposed model are discussed and compared with each other. The models evaluated the amount of transfer of heat and pressure drop. An analysis is conducted Numerical based on full factorial DOE (design of experiments) to create a model by means of different parameters such as flow rates and temperatures. The developed model is then tested and validated by comparing the consequences with the numerical results. Performance evaluation for heat exchangers of shell and tube type is developed using Ansys. This paper suggests a novel perspective and evaluates Reliable Performance Assessment of Heat Exchanger using the DOE, ANSYS. Thus, model still have chance to be improved.