The article presents the comparative study of topological properties for various Mesh-based networks. The objective of the study is to find best performing Mesh variant in terms of topological parameters and to find a suitable network which can be more feasible to use in data centers. For our analysis, variants of Mesh networks such as Mesh, D-Mesh, X-Mesh, and Z-Mesh are considered. The various topological parameters like Diameter, Average Distance, Message Density, and Cost are evaluated for considered topologies using MATLAB tools. The performance analysis is carried out on the basis of complexity, cost-effectiveness, fault tolerance, and reliability. The effect of waiting time and total execution time has also been considered to analyze the performance of the considered system. A comparative study is carried out, and graphs are depicted to understand their performances in detail. Best results are obtained for different parameters. The present study concludes with the overall performance track for the family of Mesh networks.