Mesocorticolimbic Dopaminergic Network: Functional and Regulatory Roles.

articleMesocorticolimbic dopaminergic network: functional and regulatory rolesM. Le Moal, and H. SimonM. Le Moal, and H. SimonPublished Online:01 Jan 1991https://doi.org/10.1152/physrev.1991.71.1.155MoreSectionsPDF (25 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByAdolescence as a neurobiological critical period for the development of higher-order cognitionNeuroscience & Biobehavioral Reviews, Vol. 94Body mass variability is represented by distinct functional connectivity patternsNeuroImage, Vol. 181Selective dopamine D3 receptor antagonist YQA14 inhibits morphine-induced behavioral sensitization in wild type, but not in dopamine D3 receptor knockout mice17 September 2018 | Acta Pharmacologica Sinica, Vol. 74Thioglycolic acid-capped CdS quantum dots modified with $$\hbox {Co}^{2+}$$Co2+ as a fluorescent sensor for dopamine27 July 2018 | Bulletin of Materials Science, Vol. 41, No. 4Gene x environment interactions in conduct disorder: 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1-2Sexual motivation: involvement of endogenous opioids in the ventral tegmental areaBrain Research, Vol. 729, No. 1Induction of locomotor activity by the glutamate antagonist DNQX injected into the ventral tegmental areaBrain Research, Vol. 728, No. 2Administration of amphetamine does not increase the functional efficacy of dopaminergic grafts made in infancyBrain Research, Vol. 708, No. 1-2Restlessness: The Anatomy of a Neuropsychiatric Symptom26 June 2016 | Australian & New Zealand Journal of Psychiatry, Vol. 30, No. 1N-methyl-d-aspartic acid biphasically regulates the biochemical and electrophysiological response of A10 dopamine neurons in the ventral tegmental area: in vivo microdialysis and in vitro electrophysiological studiesBrain Research, Vol. 666, No. 2Extracellular dopamine and its metabolites in the nucleus accumbens of fischer and lewis rats: Basal levels and cocaine-induced changesLife Sciences, Vol. 56, No. 6Dopamine D1 receptor mutant mice are deficient in striatal 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regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotypeMolecular Brain Research, Vol. 24, No. 1-4BAP/SKB Young Psychopharmacologist Award Towards a neuroendocrinology of obsessive-compulsive disorder1 July 2016 | Journal of Psychopharmacology, Vol. 8, No. 4Chronic social stress conditions differentially modify vulnerability to amphetamine self-administrationBrain Research, Vol. 649, No. 1-2Effects of intraaccumbens injections of dopamine agonists and antagonists on sucrose and sucrose-ethanol reinforced respondingPharmacology Biochemistry and Behavior, Vol. 48, No. 1Role of adenosine A2a receptors in the nucleus accumbensProgress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 18, No. 3Transmitter release from transplants of fetal ventral mesencephalon or locus coeruleus in the rat frontal cortex and nucleus accumbens: effects of pharmacological and behaviorally activating stimuliBrain Research, Vol. 641, No. 2Effects of amperozide on schedule-induced polydipsia in ratsEuropean Journal of Pharmacology, Vol. 256, No. 2The relationship between self-stimulation and sniffing in rats: does a common brain system mediate these behaviors?Behavioural Brain Research, Vol. 61, No. 2D2 dopamine receptor gene and cigarette smoking: A reward gene?Medical Hypotheses, Vol. 42, No. 4Heterogeneity of evoked dopamine overflow wihin the striatal and striatoamygdaloid regionsNeuroscience, Vol. 59, No. 2Slowness of movement in melancholic depressionBiological Psychiatry, Vol. 35, No. 4Postnatal changes in [3H]mazindol-labelled dopamine uptake sites in the rat striatum following prenatal cocaine exposureBrain Research, Vol. 637, No. 1-2Effects of ventral striatal 6-OHDA lesions or amphetamine sensitization on ethanol consumption in the ratPharmacology Biochemistry and Behavior, Vol. 47, No. 2Locomotor activation induced by MK-801 in the rat: postsynaptic interactions with dopamine receptors in the ventral striatumEuropean Journal of Pharmacology, Vol. 251, No. 2-3Dopamine receptors: Molecular biology, biochemistry and behavioural aspectsPharmacology & Therapeutics, Vol. 64, No. 2Unilateral stimulation or removal of rat vibrissae: Analysis of nerve growth factor and tyrosine hydroxylase mRNA in the brainBehavioural Brain Research, Vol. 60, No. 1Anterograde and retrograde tracing of projections from the ventral tegmental area to the hippocampal formation in the ratBrain Research Bulletin, Vol. 33, No. 4Central D2 Receptors and Negative Symptoms of Schizophrenia2 January 2018 | British Journal of Psychiatry, Vol. 164, No. 01Effects of rapid eye movement sleep deprivation on the properties of striatal dopaminergic systemPharmacology Biochemistry and Behavior, Vol. 46, No. 4Individual differences in the psychomotor effects of morphine are predicted by reactivity to novelty and influenced by corticosterone secretionBrain Research, Vol. 623, No. 2An acute dose of δ9-tetrahydrocannabinol affects behavioral and neurochemical indices of mesolimbic dopaminergic activityBehavioural Brain Research, Vol. 57, No. 1Individual differences in behavioral responses to novelty in rats. Possible relationship with the sensation-seeking trait in manPersonality and Individual Differences, Vol. 15, No. 4Neurotensin injected into the nucleus accumbens blocks the psychostimulant effects of cocaine but does not attenuate cocaine self-administration in the ratBrain Research, Vol. 622, No. 1-2Basal and stress-induced corticosterone secretion is decreased by lesion of mesencephalic dopaminergic neuronsBrain Research, Vol. 622, No. 1-2Rats orally self-administer corticosteroneBrain Research, Vol. 622, No. 1-2Midbrain dopaminergic neurons from postnatal rat in long-term primary cultureNeuroscience, Vol. 56, No. 2Involvement of D2 dopaminergic receptors in the emotional and motivational responses induced by injection of CCK-8 in the posterior part of the rat nucleus accumbensBrain Research, Vol. 617, No. 2The mesolimbic dopaminergic system exerts an inhibitory influence on brain corticosteroid receptor affinitiesNeuroscience, Vol. 55, No. 2Effects of angiotensin II on dopamine and serotonin turnover in the striatum of conscious ratsBrain Research, Vol. 613, No. 2Motor disturbances induced by an acute dose of Δ9-tetrahydrocannabinol: Possible involvement of nigrostriatal dopaminergic alterationsPharmacology Biochemistry and Behavior, Vol. 45, No. 2Sensitization to the psychomotor effects of amphetamine and morphine induced by food restriction depends on corticosterone secretionBrain Research, Vol. 611, No. 2A neurochemical model underlying differences in reaction times between introverts and extravertsPersonality and Individual Differences, Vol. 14, No. 5Effects of intracerebral dopaminergic grafts on behavioural deficits induced by neonatal 6-hydroxydopamine lesions of the mesotelencephalic dopaminergic pathwayNeuroscience, Vol. 54, No. 2Dopamine-rich grafts in the neostriatum and/or nucleus accumbens: Effects on drug-induced behaviours and skilled paw-reachingNeuroscience, Vol. 53, No. 1Effects of postnatal stress on dopamine mesolimbic system responses to aversive experiences in adult lifeBrain Research, Vol. 604, No. 1-2Higher and longer stress-induced increase in dopamine concentrations in the nucleus accumbens of animals predisposed to amphetamine self-administration. A microdialysis studyBrain Research, Vol. 602, No. 1Repeated stressful experiences differently affect the time-dependent responses of the mesolimbic dopamine system to the stressorBrain Research, Vol. 601, No. 1-2Neurotransmitter regulation of dopamine neurons in the ventral tegmental areaBrain Research Reviews, Vol. 18, No. 1Effect of dopamine agonists and antagonists on ethanol-reinforced behavior: The involvement of the nucleus accumbensBrain Research Bulletin, Vol. 30, No. 1-2Early postnatal estrogen organizes sex differences in the extinction of a CRF running responseBrain Research Bulletin, Vol. 30, No. 5-6Adenosine A2a receptors in the nucleus accumbens mediate locomotor depressionBrain Research Bulletin, Vol. 31, No. 3-4Stress-induced sensitization to amphetamine and morphine psychomotor effects depend on stress-induced corticosterone secretionBrain Research, Vol. 598, No. 1-2Nonhuman behavioral models in the genetics of disturbed behaviorJournal of Psychiatric Research, Vol. 26, No. 4Microinjections of dopamine agonists in the nucleus accumbens increase ethanol-reinforced respondingPharmacology Biochemistry and Behavior, Vol. 43, No. 1Effects of morphine on acquisition and maintenance of ethanol and water intake patterns in ratsAlcohol, Vol. 9, No. 5Microinjection of opioid antagonists into the substantia nigra reduces stress-induced eating in ratsBrain Research, Vol. 584, No. 1-2The effects of prenatal cocaine exposure on spontaneously active midbrain dopamine neurons in adult male offspring: an electrophysiological studyBrain Research, Vol. 586, No. 1Autoradiographic distribution of receptors to FLFQPQRFamide, a morphine-modulating peptide, in rat central nervous systemNeuroscience, Vol. 49, No. 1Behavioral effects of modulators of ATP-sensitive K+ channels in the rat dorsal pallidumEuropean Journal of Pharmacology, Vol. 217, No. 1Regional differences in the regulation of dopamine and noradrenaline release in medial frontal cortex, nucleus accumbens and caudate-putamen: a microdialysis study in the ratBrain Research, Vol. 581, No. 2Level of haloperidol in plasma is related to electroencephalographic findings in patients who improvePsychiatry Research, Vol. 42, No. 2Repeated stressful experiences differently affect limbic dopamine release during and following stressBrain Research, Vol. 577, No. 2Intraventricular administration of D-Ala2-Met5-enkephalinamide induces rapid recovery of responding for electrical brain stimulation from the ventral tegmental area following uncontrollable footshockBrain Research Bulletin, Vol. 28, No. 2Drugs of abuse: anatomy, pharmacology and function of reward pathwaysTrends in Pharmacological Sciences, Vol. 13Dopaminergic activity is reduced in the prefrontal cortex and increased in the nucleus accumbens of rats predisposed to develop amphetamine self-administrationBrain Research, Vol. 567, No. 1Functions of the limbic system in the brain More from this issue > Volume 71Issue 1January 1991Pages 155-234 Copyright & PermissionsCopyright © 1991 the American Physiological Societyhttps://doi.org/10.1152/physrev.1991.71.1.155PubMed1986388History Published online 1 January 1991 Published in print 1 January 1991 Metrics