Method of AUC Estimation from Sparse Sampling Data.

Hidefumi KASAI,Toshio HASHIMOTO,Masayuki YAMADA,Hideyuki SAKAKI,Jun HANDA,Tsuyoshi TAKIZAWA,Atsuyoshi HIRATA

Drug Metabolism and Pharmacokinetics（2001）SCI 4区

Ad Hoc Committee on Statistics

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摘要

Statistical analysis method on nonclinical pharmacokinetic data was studied. In this paper, the AUC estimation with its variance for sparse sampling data was considered. The methods to evaluate the variance of AUC based on the mean concentration and also to estimate the approximated confidence interval were presented.

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