[Mezlocillin: a Penicillin from the Acylureido Series. Synthesis and Chemical Properties].

Mezlocillin, 6-[D-2-(2-Oxo-3-mesyl-imidazolidine-1-carboxamido)- 2-phenylacetamido]-penicillanic acid, is a new semisynthetic acylureido-penicillin with a broad spectrum of antibacterial activity. The synthesis of mezlocillin from ampicillin and from 6-aminopenicillanic acid and the physicochemical properties are described. Mezlocillin is cleaved by penicillinase to the penicilloate which is degraded further by acids to the penilloate.