ARTICLESMorphology and Enumeration of Human Blood PlateletsGeorge Brecher, and Eugene P. CronkiteGeorge Brecher, and Eugene P. CronkitePublished Online:01 Dec 1950https://doi.org/10.1152/jappl.1950.3.6.365MoreSectionsPDF (2 MB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInEmail Previous Back to Top FiguresReferencesRelatedInformationCited ByMicroscopic malaria parasitemia diagnosis and grading on benchmark datasets12 September 2018 | Microscopy Research and Technique, Vol. 28Pro-inflammatory response and hemostatic disorder induced by venom of the coral snake Micrurus tener tener IN C57BL/6 miceToxicon, Vol. 150Comparison of Automated Platelet Counts and Potential Effect on Transfusion Decisions in Cancer Patients1 November 2013 | American Journal of Clinical Pathology, Vol. 140, No. 5Performance Evaluation of the Complete Blood Count and White Blood Cell Differential Parameters Obtained Using a Celltack F Automated Hematology AnalyzerLaboratory Hematology, Vol. 10, No. 1Platelets are essential for leukocyte recruitment in allergic inflammationJournal of Allergy and Clinical Immunology, Vol. 112, No. 1Changes on hemostatic parameters induced by 17β-estradiol, ethinylestradiol, and the 17β-aminoestrogen pentolame in the male Wistar ratSteroids, Vol. 67, No. 13-14A Rapid and Accurate Closed-Tube Immunoassay for Platelets on an Automated Hematology Analyzer1 July 2000 | American Journal of Clinical Pathology, Vol. 114, No. 1Platelet Aggregation in Head and Neck Tumors in ChinaThe Laryngoscope, Vol. 107, No. 8Biological properties of the venom of the Papuan black snake (Pseudechis papuanus): Presence of a phospholipase A2 platelet inhibitorToxicon, Vol. 32, No. 8Protective effects of bay u 3405, a thromboxane A2 receptor antagonist, in endotoxin shockPharmacological Research, Vol. 30, No. 2Possible involvement of oxygen-derived free radicals in abnormal hemostasis induced by SART stress (repeated cold stress) in laboratory animalsThrombosis Research, Vol. 72, No. 4Effect of hirudin on platelet deposition to an artificial surface during low-stress shear flow of whole bloodBiomaterials, Vol. 14, No. 11Circulating Platelet Aggregates Indicative of in Vivo Platelet Activation in Pulmonary Hypertension2 July 2016 | Angiology, Vol. 44, No. 9Characterization of platelet hypofunctions in rats under SART stress (repeated cold stress)Thrombosis Research, Vol. 69, No. 2Platelet activating factor interaction with tumor necrosis factor and myocardial depressant factor in splanchnic artery occlusion shockEuropean Journal of Pharmacology, Vol. 222, No. 1Idiopathic Thrombocytopenic Purpura In Infants Under 6 Months of Age2 July 2016 | Clinical Pediatrics, Vol. 31, No. 10Detection of distinct isoform patterns of the β-amyloid precursor protein in human platelets and lymphocytesNeurobiology of Aging, Vol. 13, No. 3Platelet hypoaggregability in rats exposed to SART stress (repeated cold stress)Thrombosis Research, Vol. 65, No. 4-5Cloricromene, a coumarine derivative, protects against lethal endotoxin shock in ratsEuropean Journal of Pharmacology, Vol. 210, No. 2Platelet function in Watanabe heritable hyperlipidemic rabbits. Decreased sensitivity to thromboxane A2.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, Vol. 11, No. 3Platelet activating factor involvement in splanchnic artery occlusion shock in ratsEuropean Journal of Pharmacology, Vol. 192, No. 1Coagulopathy and haemorrhage in human victims of Bothrops jararaca envenoming in BrazilToxicon, Vol. 29, No. 8Systemic haemorrhage in rats induced by a haemorrhagic fraction from Bothrops jararaca venomToxicon, Vol. 29, No. 9Protective effects of ONO-3307, a new synthetic protease inhibitor against experimental disseminated intravascular coagulation in ratsThrombosis Research, Vol. 60, No. 1Pulmonary hypertension and platelet function30 June 2016 | Perfusion, Vol. 5, No. 4Aggregation of platelets in whole blood from children with pulmonary hypertensionInternational Journal of Cardiology, Vol. 28, No. 2Analysis of atherosclerosis susceptibility in mice with genetic defects in platelet function.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., Vol. 10, No. 4Inhibition of platelet aggregation by a whole cell extract from strains of group B streptococcusThrombosis Research, Vol. 58, No. 3Activation of the coagulation cascade in falciparum malariaTransactions of the Royal Society of Tropical Medicine and Hygiene, Vol. 83, No. 6Megakaryocytopoiesis in spontaneously hypertensive rats (SHR)Thrombosis Research, Vol. 53, No. 6Acute phase reaction, fibrinogen level and thrombus sizeThrombosis Research, Vol. 53, No. 5[13] Determination of platelet volume and numberCharacterization of a mouse model of chronic uremiaUrological Research, Vol. 16, No. 2Is urinary infection a risk factor for ischemic cerebrovascular disease?Medical Hypotheses, Vol. 23, No. 2Plasma and platelet skimming at T-junctionsThrombosis Research, Vol. 45, No. 5Quantitation of platelet preservation with prostanoids during simulated bypassJournal of Surgical Research, Vol. 42, No. 1Effects of bacterial endotoxin and platelet activating factor (PAF) on human platelet aggregation in native whole bloodThrombosis Research, Vol. 44, No. 5Effects of blood dilution on electrical impedance aggregometryThrombosis Research, Vol. 42, No. 6Preparation of Small Volume, Leuko and Erythrocyte Very Poor Platelet Concentrates13 March 2018 | The International Journal of Artificial Organs, Vol. 9, No. 3Chromogenic assay of endotoxin in platelet poor or rich plasmaThrombosis Research, Vol. 41, No. 3The interaction of β-adrenoceptor blocking drugs with platelet aggregation, calcium displacement and fluidization of the membraneBiochimica et Biophysica Acta (BBA) - Biomembranes, Vol. 821, No. 2Substitution of antithrombin III in shock and DIC: A randomized studyThrombosis Research, Vol. 39, No. 1Hirudin insensitive thrombin-stimulated platelet releaseThrombosis Research, Vol. 37, No. 4Effect of ticlopidine on platelet aggregation, adherence to damaged vessels, thrombus formation and platelet survivalThrombosis Research, Vol. 37, No. 1Endotoxin-induced disseminated intravascular coagulation in vitamin E deficient ratsToxicology and Applied Pharmacology, Vol. 74, No. 2Toxicological assessment of the hemostatic system, regulatory requirements, and industry practiceRegulatory Toxicology and Pharmacology, Vol. 4, No. 1Coagulant activities of platelets in coronary artery disease.Circulation, Vol. 69, No. 1The effects of defibrinogenation with batroxobin on endotoxin-induced disseminated intravascular coagulation in ratsThrombosis Research, Vol. 31, No. 5Protective effects of thromboxane A2 on endotoxin shockProstaglandins, Leukotrienes and Medicine, Vol. 11, No. 2Effect of dipyridamole on experimental disseminated intravascular coagulation in ratsThrombosis Research, Vol. 29, No. 6Interaction of platelets and fibrin with injured rabbit aortic neointima. Effect of prostaglandin I2 and heparin.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., Vol. 3, No. 2Inhibition of human platelet function by verapamilThrombosis Research, Vol. 28, No. 4Platelet survival and thrombosis.Arteriosclerosis: An Official Journal of the American Heart Association, Inc., Vol. 2, No. 6Trypanosoma congolense: Thrombocyte survival in infected steersExperimental Parasitology, Vol. 54, No. 1Substitution therapy with an antithrombin III concentrate in shock and DICThrombosis Research, Vol. 27, No. 3Cyclic nucleotide phosphodiesterase and aggregation in platelets from diabetic ratsMetabolism, Vol. 31, No. 7Effects of Charcoal Hemoperfusion with Prostacyclin on the Coagulation-fibrinolysis System and Platelets of Patients with Fulminant Hepatic Failure — Preliminary Observations16 April 2018 | The International Journal of Artificial Organs, Vol. 5, No. 4Aspirin inhibits rat megakaryocyte thromboxane synthesisProstaglandins, Vol. 23, No. 6Inhibition by anticoagulant drugs of the progressive hypertension and uremia associated with renal infarction in ratsThrombosis Research, Vol. 26, No. 4Acute pulmonary hypertension and lung thromboxane release after endotoxin infusion in normal and leukopenic sheep.Circulation Research, Vol. 50, No. 5Thromboxane and pulmonary hypertension following E. coli endotoxin infusion in sheep: Effect of an imidazole derivativeProstaglandins, Vol. 23, No. 3The effect of acute changes in arterial blood pH and pO2 on platelet aggregationMicrovascular Research, Vol. 22, No. 3Fibrinogen binding and ADP-induced aggregation in platelets from diabetic subjectsThrombosis Research, Vol. 24, No. 1-2Phospholipid methylation and human platelet functionBiochemical Pharmacology, Vol. 30, No. 15Effects of clofibrate and 6-substituted chroman analogs on human platelet function:Biochemical Pharmacology, Vol. 30, No. 14Platelet function and antithrombins in hyperlipoproteinemia type IIaThrombosis Research, Vol. 22, No. 4Platelet adherence to collagen: effect of erythrocytesThrombosis Research, Vol. 22, No. 4Laboratory evidence of DIC under FEIBA treatment of a hemophilic patient with intracranial bleeding and high titre factor VIII inhibitorThrombosis Research, Vol. 22, No. 1-2Preoperative prednisone therapy in platelet function disordersThrombosis Research, Vol. 21, No. 6Platelets, thromboembolism and mitral valve prolapse.Circulation, Vol. 63, No. 3Platelet function in hypertension and effect of therapyThe American Journal of Cardiology, Vol. 47, No. 2Growth pattern of a transplantable acute myeloid leukemia in the ratEuropean Journal of Cancer (1965), Vol. 17, No. 2The effect of betaadrenoceptor blocking drugs on malondialdehyde production in the rat plateletsThrombosis Research, Vol. 21, No. 4-5Activity of antithrombin III and effect of heparin on coagulation in shockThrombosis Research, Vol. 19, No. 6Clinical and experimental studies on the action of ethamsylate on haemostasis and on platelet functionsThrombosis Research, Vol. 19, No. 6Thromboxane production and platelet aggregation in diabetic subjects with clinical complicationsThrombosis Research, Vol. 19, No. 1-2The differential inhibition of prostaglandin synthesis in platelets and vascular tissue in response to aspirinProstaglandins and Medicine, Vol. 4, No. 6Protective effects of thromboxane synthetase inhibitors in rats in endotoxic shock.Circulation Research, Vol. 46, No. 6The influence of disseminated intravascular coagulation on renal function after experimental hemorrhagic shockResuscitation, Vol. 8, No. 1Distribution of 14C-labelled 2-[p-(1-oxo-2-isoindolinyl)phenyl] butyric acid, (indobufen or K 3920) in blood, platelets and platelet componentsThrombosis Research, Vol. 17, No. 3-4In vivo assessment in sheep of thromboresistant materials by determination of platelet survival.Circulation Research, Vol. 46, No. 1Platelet coagulant activities in arterial occlusive disease of the eye.Stroke, Vol. 10, No. 5Heparin Bleeding Due to Qualitative Platelet Dysfunction2 July 2016 | Angiology, Vol. 30, No. 9Preservation of human platelets with prostaglandin E1 during in vitro simulation of cardiopulmonary bypass.Circulation Research, Vol. 44, No. 3Abnormalities of platelet aggregation in sickle cell anemia presence of a plasma factor inhibiting aggregation by ristocetinThrombosis Research, Vol. 14, No. 2-3Platelet aggregation across the myocardial vascular bed in man: I. 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Correlation of binding with induction of platelet aggregationThrombosis Research, Vol. 15, No. 5-6Platelet survival in diabetes mellitus using an aspirin-labelling techniqueThrombosis Research, Vol. 15, No. 5-6Poor discriminating power of fibrinogen-Sepharose towards plasma fibrinogen, fibrin Des-AA and fibrin Des-AABB monomers, as studied by labelled proteins, laser nephelometric fr-antigen and ria-FPA quantitationThrombosis Research, Vol. 16, No. 1-2Methodology of investigations on platelets in drug-safety evaluationPharmacology & Therapeutics, Vol. 5, No. 1-3PROSTACYCLIN CAN REPLACE HEPARIN IN HÆMODIALYSIS IN DOGSThe Lancet, Vol. 312, No. 8099Cyclic nucleotides and aggregation in platelets of spontaneously hypertensive rats.Circulation Research, Vol. 43, No. 4Platelet antithrombin deficiencyThe American Journal of Medicine, Vol. 65, No. 3Somatostatin: Influence on hemostasis—A reviewMetabolism, Vol. 27, No. 9An investigation of thrombasthenic platelets with selected lectinsThrombosis Research, Vol. 13, No. 3Trypanosoma congolense: Thrombocytopenia in experimentally infected cattleExperimental Parasitology, Vol. 45, No. 1Diurnal hemostatic changes in the ratThrombosis Research, Vol. 12, No. 6A case of IgM antibodies which inhibit the contact activation of blood coagulationThrombosis Research, Vol. 12, No. 5The influence of the pituitary on arterial intimal proliferation in the rat.Circulation Research, Vol. 42, No. 5Thrombogenicity of an artificial surface is decreased by the antiplatelet agent ditazolThrombosis Research, Vol. 12, No. 1The production of disseminated intravascular coagulation (DIC) by spaced injections of endotoxin in nonpregnant, normolipaemic ratsThrombosis Research, Vol. 12, No. 1Platelet adherence to collagen: A simple, reproducible, quantitative method for its measurementThrombosis Research, Vol. 11, No. 6Postoperative hemorrhage associated with carbenicillin administrationThe American Journal of Surgery, Vol. 134, No. 5A Bleeding Syndrome in Infants due to Acquired Prothrombin Complex Deficiency2 July 2016 | Clinical Pediatrics, Vol. 16, No. 11Factor XI deficiency, juvenile rheumatoid arthritis and systemic lupus erythematosusThe American Journal of Medicine, Vol. 63, No. 2The role of red cells in haemostatic plug formation in the isolated rabbit mesenteryThrombosis Research, Vol. 11, No. 1Hematologic changes following burnsJournal of Surgical Research, Vol. 22, No. 6Relationships between blood platelet and erythrocyte formationLife Sciences, Vol. 20, No. 9An abnormal fibrinogen in a Venezuelan familyThrombosis Research, Vol. 10, No. 2Effect of exercise on F VIII-complex: Proportional increase of ristocetin cofactor (von Willebrand factor) and F VIII-AGN, but disproportional increase of F VIII-AHFThrombosis Research, Vol. 10, No. 1Comparative studies on the glycoprotein composition of mammalian plateletsComparative Biochemistry and Physiology Part B: Comparative Biochemistry, Vol. 56, No. 4Effect of induced thrombocytopenia on experimental circulatory shockJournal of Surgical Research, Vol. 21, No. 6The in vivo increase of factor VIII activity by 2,3-diphosphoglycerateThrombosis Research, Vol. 9, No. 6The interaction of platelets with a tritium-labelled heparinThrombosis Research, Vol. 9, No. 6Effect of aspirin on prostaglandin synthesis by human plateletsProstaglandins, Vol. 12, No. 5Deep Vein Thrombosis Treated With Streptokinase or Heparin2 July 2016 | Angiology, Vol. 27, No. 10In vitro and in vivo studies of a new series of synthetic thrombin-inhibitors (OM-inhibitors)Thrombosis Research, Vol. 8Integrated analysis of hemorrhagic-thrombotic tendencyThrombosis Research, Vol. 8Influence of humoral shock factors on in vitro aggregation of dog plateletsThrombosis Research, Vol. 8, No. 5Influence of time, temperature and platelet concentration on dog platelet aggregationThrombosis Research, Vol. 8, No. 4Failure of AHF concentrate to control bleeding in von Willebrand's diseaseThe American Journal of Medicine, Vol. 60, No. 3The effects of acute normovolemic hemodilution on coagulation and blood utilization in major surgeryJournal of Surgical Research, Vol. 20, No. 3Alterations of hemostasis associated with cardiopulmonary bypassThrombosis Research, Vol. 8, No. 3The influence of platelet aggregation inhibitors on metastasis formation in mice (3LL)Zeitschrift f�r Krebsforschung und Klinische Onkologie, Vol. 86, No. 3Von Willebrand factor activity in normal subjects: Sex difference and variabilityThrombosis Research, Vol. 7, No. 6Hemostatic Defects Induced by Cardiopulmonary Bypass18 August 2016 | Vascular Surgery, Vol. 9, No. 4A defibrination syndrome in calves caused by histotropic larvae of Oesophagostomum radiatumJournal of Comparative Pathology, Vol. 85, No. 3Induction of disseminated intravascular coagulation by endotoxin and saline loading in rats I. 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Vol. 11, No. 4Changes in the Hemostatic Mechanism After Myocardial InfarctionCirculation, Vol. 43, No. 4The clotting system of monkeys: A comparison of coagulation factors and tests between cynomolgus monkeys (Macaca irus) and humansComparative Biochemistry and Physiology Part A: Physiology, Vol. 38, No. 1Release of metabolic enzymes from platelets during blood clotting of man, dog, rabbit and ratClinica Chimica Acta, Vol. 30, No. 1LONG-TERM HEPATIC SUPPORT BY INTERMITTENT MULTI-SPECIES LIVER PERFUSIONSThe Lancet, Vol. 296, No. 7669EFFECT OF ORAL CONTRACEPTIVES ON LIPOPROTEIN LIPASE ACTIVITY AND PLATELET STICKINESSThe Lancet, Vol. 296, No. 7668∈-AMINOCAPROIC ACID IN PREOPERATIVE CORRECTION OF HÆMOSTATIC DEFECT IN CYANOTIC CONGENITAL HEART-DISEASEThe Lancet, Vol. 295, No. 7658Chronic defibrination syndrome due to a giant hemangioma associated with microangiopathic hemolytic anemiaThe American Journal of Medicine, Vol. 46, No. 6Erythrocyte metabolism in the bottle-nosed dolphin, Tursiops 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RETENTION OF NORMAL HOMŒOSTATIC CONTROL IN CHRONIC GRANULOCYTIC LEUKÆMIAThe Lancet, Vol. 290, No. 7530Congenital deficiency of factor XIII (fibrin-stabilizing factor)The American Journal of Medicine, Vol. 43, No. 5IN-VIVO AND IN-VITRO EFFECTS OF POLYVINYLPYRROLIDONE ON PLATELET ADHESIVENESS IN HUMAN BLOODThe Lancet, Vol. 290, No. 7522EFFECT OF VARIATION OF THE INTERVAL BETWEEN VENEPUNCTURE AND MEASUREMENT OF PLATELET ADHESIVENESS BY THE PAYLING WRIGHT METHODThe Lancet, Vol. 290, No. 7515HEPARIN TREATMENT OF HÆMORRHAGIC DIATHESIS IN CYANOTIC CONGENITAL HEART-DISEASEThe Lancet, Vol. 289, No. 7499HYPOFIBRINOGENÆMIA WITHOUT INCREASED FIBRINOLYSIS IN LEUKÆMIAThe Lancet, Vol. 289, No. 7487Thrombocytopenia Associated with Iron Deficiency Anemia17 November 2016 | Clinical Pediatrics, Vol. 5, No. 10THE BLEEDING DISORDER OF URÆMIAThe Lancet, Vol. 288, No. 7454EFFECTS OF CIGARETTE SMOKING ON SERUM-LIPIDS, BLOOD-GLUCOSE, AND PLATELET ADHESIVENESSThe Lancet, Vol. 288, No. 7456Vitamin B12, ascorbic acid and iron metabolism in scurvyThe American Journal of Medicine, Vol. 40, No. 1EFFECT OF DIPYRIDAMOLE ON HUMAN PLATELET BEHAVIOURThe Lancet, Vol. 286, No. 7413Studies of incorporation of radioactivity into lipids by human bloodMetabolism, Vol. 14, No. 4POSTOPERATIVE CHANGES IN PLATELET-CLUMPING ACTIVITYThe Lancet, Vol. 285, No. 7376Pi transport and glycolysis in leucocytes and plateletsBiochimica et Biophysica Acta (BBA) - General Subjects, Vol. 93, No. 3LIPOPROTEIN-LIPASE LEVELS AND PLATELET STICKINESS IN PATIENTS WITH ISCHÆMIC HEART-DISEASE AND IN CONTROLS, DISTINGUISHING THOSE WITH AN AFFECTED FIRST-DEGREE RELATIVEThe Lancet, Vol. 284, No. 7368LOW IN-VIVO ADHESIVE-PLATELET COUNT IN HEREDITARY HÆMORRHAGIC TELANGIECTASIAThe Lancet, Vol. 284, No. 7365Evaluation and preparation of patients with disorders of bleeding before or during surgeryThe American Journal of Cardiology, Vol. 12, No. 3Studies of Coagulation and Fibrinolysis of the Arterial and Venous Blood in Normal Subjects and Patients with AtherosclerosisCirculation, Vol. 27, No. 5Observations on the pathophysiology of Schistosomiasis mansoni in monkeysExperimental Parasitology, Vol. 13, No. 2Preservation of viable platelets in the frozen stateLife Sciences, Vol. 1, No. 7The Detection of platelet defects in patients with mild bleeding disordersThe American Journal of Medicine, Vol. 32, No. 6Congenital refractory normoblastic anemia with jaundice and ineffective erythropoiesisThe American Journal of Medicine, Vol. 32, No. 4Effect of reserpine, serotonin, and 5-hydroxytryptophan on rabbit platelet histamine in vivo and in vitroBiochemical Pharmacology, Vol. 3, No. 4DEFIBRINATION SYNDROME IN PREGNANCY VALUE OF VARIOUS DIAGNOSTIC TESTSThe Lancet, Vol. 272, No. 7060APPARENT INCREASE IN BLOOD-PROTHROMBIN DURING EXTRACORPOREAL BYPASS AND DURING SLOW COAGULATION IN SILICONED CONTAINERSThe Lancet, Vol. 271, No. 7031COAGULABILITY OF THE BLOOD IN ISCHÆMIC HEART-DISEASEThe Lancet, Vol. 270, No. 6993The coincidence of hemoglobin J and Fanconi's syndrome of hypoplastic anemia with hypoplasia of the spleen in a young manThe American Journal of Medicine, Vol. 23, No. 2Differential diagnosis, pathogenesis and treatment of the thrombocytopenic purpurasThe American Journal of Medicine, Vol. 14, No. 4 More from this issue > Volume 3Issue 6December 1950Pages 365-377 https://doi.org/10.1152/jappl.1950.3.6.365PubMed14794596History Published online 1 December 1950 Published in print 1 December 1950 PDF download Metrics Downloaded 2,459 times
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