Three cases of neurobrucellosis are reported. Clinical manifestations in the first case were suggestive of cerebral ischemia, with transient ischemic attacks followed by sudden, stroke (after intradermal testing with melitin, suggesting an immunoallergic mechanism) in the vertebrobasilar territory. The second patient developed cauda equina syndrome with progressive hydrocephalus which responded to intrathecal corticosteroid therapy. Clinical findings in the third patient were consistent with acute meningoencephalitis with positive cerebrospinal fluid cultures for Brucella melitensis. These case-reports suggest that neurobrucellosis is still a current problem in southern France and can be responsible for a very broad spectrum of clinical patterns.
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