The second session of the 2nd Joint BSTP/ESTP Toxicologic Pathology Congress, Manchester, UK, September 23-26, 2025, entitled “New Approach Methodologies for Carcinogenicity Evaluation,” was dedicated to innovative strategies for assessing carcinogenic risks in various substances, particularly in drug development and agrochemicals. The two-year rodent cancer bioassay in two species (generally rats and mice) is currently the standard method for assessing the carcinogenic potential of agrochemicals for humans. However, this method has some weaknesses and is subject to ethical and scientific debate. Attempts to waive those studies have been proposed, but more relevant methods using less or preferably no animals are still being sought. The session featured five key presentations that explored cutting-edge methodologies aimed at improving the accuracy and reliability of carcinogenicity predictions. Below is a summary of each talk presented.
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