Novel 3-N-aminoglycoside Acetyltransferase Gene, Aac(3)-Ic, from a Pseudomonas Aeruginosa Integron.

ABSTRACT A novel gene, aac ( 3 )- Ic , encoding an AAC(3)-I aminoglycoside 3- N -acetyltransferase, was identified on a gene cassette inserted into a Pseudomonas aeruginosa integron that also carries a bla VIM-2 and a cmlA7 gene cassette. The aac ( 3 )- Ic gene product is 59 and 57% identical to AAC(3)-Ia and AAC(3)-Ib, respectively, and confers resistance to gentamicin and sisomicin.