A large number of sequences are being generated by the various genome sequencing projects. One of the major challenges in the biocomputing field is to derive valuable information from these protein sequences. The first prerequisite in this process is to access up-to-date sequence and structure databanks (e.g. EMBL, GenBank, SWISS-PROT, Protein Data Bank; for a catalogue, see 1 Kreil D.P. Etzold T. DATABANKS – a catalogue database of molecular biology databases. Trends Biochem. Sci. 1999; 24: 155-157 Abstract Full Text Full Text PDF PubMed Scopus (12) Google Scholar ) maintained by several biocomputing centres, such as NCBI, EBI, EMBL, SIB and INFOBIOGEN. Ideally, sequences are analysed using a maximal number of methods on a minimal number of different Web sites. To achieve this, we developed a Web server called [email protected] (Network Protein Sequence Analysis, http://pbil.ibcp.fr/NPSA) that became available in 1998. [email protected] is the protein sequence analysis Web server of the Pôle BioInformatique Lyonnais, a group of biocomputing teams (http://pbil.univ-lyon1.fr), and provides the user with many of the most commonly used tools for protein sequence analysis.
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