OMEGA-Py is a Python 3 module dedicated to the scientific use of data provided by the Observatoire pour la Minéralogie, l'Eau, les Glaces et l'Activité (OMEGA) instrument onboard the ESA Mars Express (MEx) orbiter (Bibring et al., 2004).It has been developed as an alternative to the IDL routines (OMEGA Team, 2004) of the OMEGA legacy software provided by the instrument team for the past 20 years.