On Application of Mathematical Modeling to the Cryochemical Synthesis of Medicine Nanoforms: Temperature and Pressure Distribution

In this article we continue our previously conducted research on the construction of a mathematical model for obtaining medicinal nanoforms using cryochemical synthesis methods. In connection with the need to increase their therapeutic effectiveness, it is necessary to take into account the particles size, structure and shape. Thus, to reduce side effects and a toxicity we can reduce the particle size of drugs to nanoscales. It allows us to obtain highly effective drugs and to use its smaller doses. One of the most powerful new methods for obtaining nanoforms of drugs is its cryochemical synthesis. This method is a leading-edge process for producing drugs in nanoparticle form. The procedure involves vaporizing the raw drug material in a vacuum and then channeling this vapor into a stream of gas. The gas stream, now carrying the drug molecules, is directed onto an extremely cold surface where the molecules instantly condense and form nanoscale structures. The first stage of mathematical modeling of cryochemical synthesis processes was the calculation of the temperature field in the carrier gas flow interacting with the cooled surface. At this stage, taking into account the previously obtained results, we study the change in pressure and supersaturation, determining the coordinate of the formation of the first embryo and its critical size, which will allow us to describe the process of embryo growth at the next stage of constructing a mathematical model, and determine their molecular mass as they reach the cooling surface.