P15‐8: Dasatinib Induced Pulmonary Arterial Hypertension and Pleural Effusion in Post Allogenic Stem Cell Transplant Cml Patient

Background and Aims: Transthoracic echocardiography has a problem with sensitivity in detecting pulmonary hypertension associated with interstitial lung disease (PH-ILD).This study aimed to evaluate the correlation between %FVC/%DLco ratio and pulmonary hemodynamics in PH-ILD, compared with the echocardiographic tricuspid regurgitation peak gradient (TRPG).Methods: We conducted a retrospective study for patients with ILD who underwent a right heart catheterization in Nippon Medical School Hospital from April 2017 to March 2020.We statistically evaluated the correlations between % FEV/%DLco, TRPG and pulmonary hemodynamics such as systolic pulmonary artery pressure (sPAP) and mean pulmonary artery pressure (mPAP).We determined the optimal cut-off value of %FVC/%DLco and TRPG for PH-ILD defined as mPAP ≧25 mmHg.Results: A total of 15 patients were enrolled.The median % FEV/%DLco was 2.21 (IQR, 1.66-3.53).The median TRPG was 51.3 (IQR, 32.0-70.9)mmHg.The median sPAP and mPAP were 59 (IQR, 27-70) and 33 (IQR, 17-42) mmHg.% FVC/%DLco was significantly correlated with sPAP (r = 0.68, p < 0.01) and mPAP (r = 0.65, p < 0.01).TRPG was significantly correlated with sPAP (r = 0.84, p< 0.01) and mPAP (r = 0.79, p < 0.01).At the cut off value of 1.8 for %FVC/%DLco, the sensitivity and specificity were 9/9 (100%) and 9/11 (82%), respectively.At the cut off value of 50mmHg for TRPG, the sensitivity and specificity were 8/9 (89%) and 8/8 (100%), respectively.Conclusions: Our results indicate that %FEV/%DLco ratio is effective in detecting PH-ILD as well as echocardiography.