Perovskite-derived Pro-Photosensitizer Enables Sustainable Photodynamic Therapy in Hypoxia Tumors

Perovskite of superior photocatalysis renders attractive potential in photodynamic therapy (PDT), but compromise in biomedical applications due to intrinsic susceptible hydrolysis and safety concerns. Here, a trilaminar-structured, hyaluronidase-responsive pro-photosensitizer (HMT) is fabricated by perovskite (MASnI3)-titanium dioxide (TiO2)-hyaluronic acid (HA) ploygel passivator for advanced cytoplasm-specific sustainable PDT. Structurally, an efficient electron-hole transfer medium of TiO2 was deposited onto MASnI3 for hydrolysis-resistance, which could give robust hydroxyl radical production in hypoxia. The HMT is passivated by HA-gel clicking for bio-stabilization, tumor-specific penetration and cellular internalization. The HA-corona detachment by hyaluronidase in tumor triggers revitalization of photoinduced-hydrogen-abstraction, promising instant ROS generation. After topical administration, HMT induces complete tumor elimination via mitochondria damage upon multi-cycle NIR irradiation. Moreover, no side-effect is noted in toxicity study, potentially profiting from topical application, tumor targeting and minimized dosage by multi-cycle irradiation. Collectively, we herein propose a pioneering perovskite photosensitizer for non-oxygen dependent PDT.