Piperidine-based Renin Inhibitors: Upper Chain Optimization

Olivier Corminboeuf,Olivier Bezencon,Lubos Remen,Corinna Grisostomi,Sylvia Richard-Bildstein,Daniel Bur,Lars Prade,Panja Strickner,Patrick Hess,Walter Fischli,Beat Steiner,Alexander Treiber

Bioorganic & Medicinal Chemistry Letters（2010）SCI 4区SCI 2区

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Actel Pharmaceut Ltd

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摘要

The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibitor with a suitable profile for development is described.

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关键词

Hypertension,Renin angiotensin aldosterone system,Renin inhibitor,Piperidine

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