The aim of our study was to develop a more advanced method of using some already existing drugs by synthesizing a multicomponent biopolymeric nanocomposite material, which would function as a local drug release system. Thus, we started from simple polylactic-co-glycolic acid (PLGA) nanoparticles, synthesized by the double emulsion method. Then we functionalized the surface of the obtained material with polydopamine (PDA) to which we bound bisphosphonates (used in the current medical practice for the treatment of osteosarcoma). This resulted in a composite material with improved properties compared to constituent materials. The synthesized polymer biocomposites were characterized by SEM (morphological aspects) and Diffusion Light Scattering (DLS) (granulometric dimensions, zeta potential). The chosen synthesis method is simple, inexpensive, with easily adjustable parameters. The theoretical studies carried out regarding the bisphosphonate-polydopamine interaction showed a better stability for the risedronate interaction complex which agrees with the experimental data obtained for it.
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