This study assessed posttraumatic growth (PTG) among nurses during a health crisis and identified whether resilience, perceived organizational support, and well-being resource use moderate the link between negative occupational experiences (NOE) and PTG. In fall 2020, 816 nurses from a US health system completed surveys on NOE, PTG, resilience, support, and resource use. Linear regression analyzed associations and moderation, adjusting for workload and demographics. NOE predicted PTG in adjusted models (β = 0.47, p = 0.0002), strengthening in the full model (β = 0.79 per NOE unit, 95% CI [0.50, 1.01], p < 0.0001). PTG increased with organizational support (p = 0.001) and resource use (p = 0.003). Resilience showed a mixed interaction with NOE (p = 0.047), but no direct association. Perceived organizational support and well-being resource use represent actionable targets for fostering PTG.e.