The progression of power transformer core is usually determined by the core diameter and the width and thickness of the silicon-steel sheet is determined by the graphing method. Therefore, coil section can’t be fully utilized. To analyze the manufacturing characteristics of power transformer core columns from the performance and material savings and the nonlinear integer regression programming model is established. Taking the circumscribed circle diameter is 800mm, progression equal to 17 as an example. The optimized design of column section is solved by using the MATLAB. The results show that the optimized design can increase the cross-section fill factor by 3.8% and the diameter of the core columns larger, the optimization results better.